Advanced Organic Reactions

<h2><span style="font-size: x-large;"><span style="color: blue;">Advanced Organic Reactions -Chemistry 223</span></span></h2><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjwy9RWdHRe59Jb0zUUhZcF6TuP4Z1sUZE15ishkjKCVFAUDW2CCrZIlC4IARsZ0D_xh16xCLvagN073Ev2CWMK7c2AtDtthjOYrumB2WdNnv3NDgjFztCjRE7n68IhPRJ33hVO1PA6BtA/s1600/Advanced+Organic+Reactions-Chemistry+and+creativity.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Advanced Organic Reactions-Chemistry and creativity" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjwy9RWdHRe59Jb0zUUhZcF6TuP4Z1sUZE15ishkjKCVFAUDW2CCrZIlC4IARsZ0D_xh16xCLvagN073Ev2CWMK7c2AtDtthjOYrumB2WdNnv3NDgjFztCjRE7n68IhPRJ33hVO1PA6BtA/s1600/Advanced+Organic+Reactions-Chemistry+and+creativity.jpg" title="Advanced Organic Reactions-Chemistry and creativity" /></a></div><a name="more"></a><br /><div class="separator" style="clear: both; text-align: center;"></div><a href="https://www.blogger.com/null" name="more"></a><br /><span style="font-size: x-large;">Description</span><br /><ul><li>F.A. Carey and R.A. Sundberg "Advanced Organic Chemistry, Part B: Reactions and Synthesis (3rd Edition)." Plenum Press 1991</li><li>J. A. March , M. B. Smith"Advanced Organic Chemistry. Reactions, Mechanisms and Structure (Fifth Edition), J. Wiley & Sons, 2001</li><li>M. B. Smith, "Organic Synthesis." McGraw-Hill 1992</li></ul><blockquote class="tr_bq"><a href="http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/chem223.htm" rel="nofollow" target="_blank">http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/chem223.htm</a></blockquote><span style="font-size: x-large;">Content</span><br /><h3><div class="separator" style="clear: both; text-align: center;"></div>1.Selectivity in Organic Chemistry<br /><br /><div class="separator" style="clear: both; text-align: center;"><a href="http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/Selectivity.pdf" target="_blank"><img alt="Chemistry and creativity" border="0" height="79" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAbu5vCznxEhtr4w3QyfoBH4hcesO3VhqEQlwEZ1oJPi1dSxw33PcQt7IFY16SN-byAyRyvE4ECPgAe9mZ3_u9yFeDRHNgOEr-syoH3xjWhOrwEsN-POzH-bloGhrj9BvUFDJ5FX7Zpp8/s1600/reading1.jpg" title="Chemistry and creativity" width="200" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://www.mediafire.com/?h4soauc7fboj96d" rel="nofollow" target="_blank"><img alt="chemistry and creativity" border="0" height="81" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div class="separator" style="clear: both; text-align: left;">2. Oxidations</div><div class="separator" style="clear: both; text-align: center;"><a href="http://forum-chemistry.blogspot.com/2014/10/chemistry-lesson-2-oxidations.html" target="_blank"><img alt="Chemistry and creativity" border="0" height="79" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAbu5vCznxEhtr4w3QyfoBH4hcesO3VhqEQlwEZ1oJPi1dSxw33PcQt7IFY16SN-byAyRyvE4ECPgAe9mZ3_u9yFeDRHNgOEr-syoH3xjWhOrwEsN-POzH-bloGhrj9BvUFDJ5FX7Zpp8/s1600/reading1.jpg" title="Chemistry and creativity" width="200" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: left;">3. Reductions</div><div class="separator" style="clear: both; text-align: center;"><a href="http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/Reductions.pdf" target="_blank"><img alt="Chemistry and creativity" border="0" height="79" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAbu5vCznxEhtr4w3QyfoBH4hcesO3VhqEQlwEZ1oJPi1dSxw33PcQt7IFY16SN-byAyRyvE4ECPgAe9mZ3_u9yFeDRHNgOEr-syoH3xjWhOrwEsN-POzH-bloGhrj9BvUFDJ5FX7Zpp8/s1600/reading1.jpg" title="Chemistry and creativity" width="200" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://www.mediafire.com/?z2p6l5s4gkmh5gm" rel="nofollow" target="_blank"><img alt="chemistry and creativity" border="0" height="81" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div class="separator" style="clear: both; text-align: left;">4.Protecting Groups</div></h3><h3><div class="separator" style="clear: both; text-align: center;"><img alt="Chemistry and creativity" border="0" height="79" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAbu5vCznxEhtr4w3QyfoBH4hcesO3VhqEQlwEZ1oJPi1dSxw33PcQt7IFY16SN-byAyRyvE4ECPgAe9mZ3_u9yFeDRHNgOEr-syoH3xjWhOrwEsN-POzH-bloGhrj9BvUFDJ5FX7Zpp8/s1600/reading1.jpg" title="Chemistry and creativity" width="200" /></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/protect.pdf" target="_blank">http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/protect.pdf</a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><img alt="chemistry and creativity" border="0" height="81" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://www.mediafire.com/?narb8v363u50o7a" rel="nofollow" target="_blank">https://www.mediafire.com/?narb8v363u50o7a</a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: left;">5. C-C Bond Formation</div></h3><h3><div class="separator" style="clear: both; text-align: center;"><img alt="Chemistry and creativity" border="0" height="79" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAbu5vCznxEhtr4w3QyfoBH4hcesO3VhqEQlwEZ1oJPi1dSxw33PcQt7IFY16SN-byAyRyvE4ECPgAe9mZ3_u9yFeDRHNgOEr-syoH3xjWhOrwEsN-POzH-bloGhrj9BvUFDJ5FX7Zpp8/s1600/reading1.jpg" title="Chemistry and creativity" width="200" /></div><div class="separator" style="clear: both; text-align: center;"><a href="http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/C-C.pdf" target="_blank">http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/C-C.pdf</a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/olefin.pdf" target="_blank">http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/olefin.pdf</a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/acetylene.pdf" target="_blank">http://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/acetylene.pdf</a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><img alt="chemistry and creativity" border="0" height="81" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></div><div class="separator" style="clear: both; text-align: center;"><a href="http://www.mediafire.com/view/chw8e7djpoc9zey/acetylene.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/chw8e7djpoc9zey/acetylene.pdf</a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="http://www.mediafire.com/view/ogzgehbz4shymya/olefin.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/ogzgehbz4shymya/olefin.pdf</a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="http://www.mediafire.com/view/gk6tbd4lewxg8at/C-C.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/gk6tbd4lewxg8at/C-C.pdf</a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: left;">6. <a href="http://www.mediafire.com/view/s4nrtvh6r2g1vt9/FGI.pdf" rel="nofollow" target="_blank">Other Functional Group Interconversions</a></div></h3><h3><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: left;">7.Ring Chemistry:</div><div class="separator" style="clear: both; text-align: left;"></div><ul><li><a href="https://www.mediafire.com/?d887apc3elcbwu1" target="_blank">Three-membered Rings </a></li><li><a href="https://www.mediafire.com/?7qjg3d07srhorul" target="_blank">Four-membered Rings </a></li><li><a href="http://www.mediafire.com/view/x7fd3guh7m944jb/baldwinsrules.pdf" target="_blank">Baldwin's Rules for Ring Closure </a></li></ul><br /><div class="separator" style="clear: both;">            J. Chem. Soc. Chem. Commun</div><div class="separator" style="clear: both;">            J. Org. Chem</div><div class="separator" style="clear: both;"></div><ul><li><a href="http://www.mediafire.com/view/s8bjgz16q52r5wj/rings5.pdf" target="_blank">Five-membered Rings </a></li><li><a href="http://www.mediafire.com/view/s8bjgz16q52r5wj/rings5.pdf" rel="nofollow" target="_blank">Six-membered Rings</a></li><li><a href="http://www.mediafire.com/view/ocloyd58y28y68o/medrings.pdf" rel="nofollow" target="_blank">Medium Sized Rings </a></li></ul><div>8.Reference</div><div><ul><li><span style="font-weight: normal;">R.K. Mackie, D.M. Smith, R.A. Aitken "Guidebook to Organic Synthesis (2nd Edition)," Longman Scientific & Technical, 1990</span></li><li><span style="font-weight: normal;">H.O. House "Modern Synthetic Reactions (second edition)," Benjamin-Cummings, 1972</span></li><li><span style="font-weight: normal;">Fieser & Fieser "Reagents for Organic Synthesis," 16 volumes, J. Wiley & Sons.</span></li><li><span style="font-weight: normal;">Trost & Fleming "Comprehensive Organic Synthesis. Selectivity, Strategy, & Efficiency in Modern Organic Chemistry," 9 volumes, Pergamon Press, 1991.</span><span style="font-weight: normal;">...............</span></li></ul></div></h3>

Advanced Organic Reactions

Advanced Organic Reactions -Chemistry 223 Description F.A. Carey and R.A. Sundberg "Advanced Organic Chemistry, Part B: Reactions and S...

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Advanced Organic Chemistry: Retrosynthesis

<h2><span style="font-size: x-large;"><span style="color: blue;">Advanced Organic Chemistry: Retrosynthesis</span></span></h2>Question 1. Propose a retrosynthetic analysis of the following two compounds. Your answer should include both the synthons, showing your thinking, and the reagents that would be employed in the actual synthesis.<br /><br />Compound A<br /><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEglmK1fKYqFC0WDLjur-OP5SFMFWFCxH6A6tRosnF1GXIdw7K-IVk3aVtG6lfmmj464r8Ijo0RtcS4__lR085R2toNgrR9RBQ-khfhY8re6cChYMJlDhqYkqX8h3nK8n7Ex3igO03B867M/s1600/Advanced+Organic+Chemistry+Retrosynthesis.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Advanced Organic Chemistry Retrosynthesis" border="0" height="235" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEglmK1fKYqFC0WDLjur-OP5SFMFWFCxH6A6tRosnF1GXIdw7K-IVk3aVtG6lfmmj464r8Ijo0RtcS4__lR085R2toNgrR9RBQ-khfhY8re6cChYMJlDhqYkqX8h3nK8n7Ex3igO03B867M/s1600/Advanced+Organic+Chemistry+Retrosynthesis.jpg" title="Advanced Organic Chemistry Retrosynthesis" width="640" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both; text-align: left;"><span style="color: red; font-size: x-large;">View:                                              <a href="http://p.pw/badEvI" rel="nofollow" target="_blank"> Download</a></span></div><br /><iframe frameborder="0" src="https://googledrive.com/host/0B1i9PwsI0eqWYmxqQzA5bEs4QVU" style="height: 550px; width: 640px;"></iframe>

Advanced Organic Chemistry: Retrosynthesis

Advanced Organic Chemistry: Retrosynthesis Question 1. Propose a retrosynthetic analysis of the following two compounds. Your answer should ...

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Advanced Organic Chemistry: Synthesis by Kenichi Ebina

<h2>Advanced Organic Chemistry: Synthesis by Kenichi Ebina</h2><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjF0xJrpvQ-ekHMcmsueE4pGo1i13vcl3vz8Jg-xe2LSvMV9eXEWNP_j4U3ANjtx0uYXIRz-Ec86g3s05XwT-ngOGnP-7c0Xx8dIUyZASnY7SOIyHFJ4zo6H5qlmcgD3ew4lmBLWBE9qX8/s1600/7-e44df.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Advanced Organic Chemistry: Synthesis by Kenichi Ebina" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjF0xJrpvQ-ekHMcmsueE4pGo1i13vcl3vz8Jg-xe2LSvMV9eXEWNP_j4U3ANjtx0uYXIRz-Ec86g3s05XwT-ngOGnP-7c0Xx8dIUyZASnY7SOIyHFJ4zo6H5qlmcgD3ew4lmBLWBE9qX8/s1600/7-e44df.jpg" title="Advanced Organic Chemistry: Synthesis by Kenichi Ebina" /></a></div><a name="more"></a><br /><h3>Advanced Organic Chemistry: Synthesis Name:Kenichi Ebina</h3><a href="https://www.blogger.com/null" name="more"></a><br />CHEM 311/511<br />First Mid-term Exam<br />Read each question carefully before answering. Be certain you understand everything the question is requesting. Do the easy questions first. If questions appear confusing or exceedingly complex, then you may need to rethink the question. Keep in mind the intended examination topics. <br />In organic chemistry, hand-drawn pictures convey specific information. Be sure the drawing you have made conveys the essential information required to answer the question. Make certain that three-dimensional pictures display the correct atom arrangements. Don't forget to include formal charges when appropriate.<br />You may use models to assist in determining answers. You may use scrap paper to work out problems before entering your final answer on the exam sheets. If necessary, you may enter exam answers on additional sheets of paper, however you must clearly indicate which problems are located on additional exam pages. <br />Note: Bonus points will be awarded for additional correct answers to questions beyond the required number.<br /><div style="text-align: center;"><br /></div><div style="text-align: center;"><span style="color: red; font-size: x-large;"><a href="http://p.pw/badEwB" rel="nofollow" target="_blank">Download</a></span><iframe frameborder="0" src="https://googledrive.com/host/0B1i9PwsI0eqWX2xVMmd0TWlPeVE" style="height: 550px; width: 640px;"></iframe></div>

Advanced Organic Chemistry: Synthesis by Kenichi Ebina

Advanced Organic Chemistry: Synthesis by Kenichi Ebina Advanced Organic Chemistry: Synthesis Name:Kenichi Ebina CHEM 311/511 First Mid-term ...

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Acetoacetic Ester Synthesis-Organic reaction

<h2 style="text-align: center;"><span style="font-size: x-large;"><span style="color: blue;">Acetoacetic Ester Synthesis</span></span></h2><div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg7X4ErBLAtiEwLzrd_6PC-kkXadhe2c1x0WsJrCx_bQKMUq-xvnPZfi5rqhlKmkGCK6eNIeVckspgJU9YERPYehw2KAO3EWF4AUJ-UK32BuyMjt9Csc-7w1_aAhIZRR9XDlCLxtl0uFPQ/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acetoacetic Ester Synthesis-Organic reaction-chemistry and creativity" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg7X4ErBLAtiEwLzrd_6PC-kkXadhe2c1x0WsJrCx_bQKMUq-xvnPZfi5rqhlKmkGCK6eNIeVckspgJU9YERPYehw2KAO3EWF4AUJ-UK32BuyMjt9Csc-7w1_aAhIZRR9XDlCLxtl0uFPQ/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" title="Acetoacetic Ester Synthesis-Organic reaction-chemistry and creativity" /></a></div><a name="more"></a><br /></div><h3><span style="color: blue; font-size: large;">Acetoacetic ester synthesis<a href="https://www.blogger.com/null" name="more"></a></span></h3>Acetoacetic ester synthesis is a chemical reaction where ethyl acetoacetate is alkylated at the α-carbon to both carbonyl groups and then converted into a ketone, or more specifically an α-substituted acetone. This is very similar to malonic ester synthesis.<br /><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgbCPbQ2SCutEgAlCd2u_fzDAIq2JO2DjomphrJPP8Vpj1YFpueeeF3vYlKlr8f8z_C39Ba1FSgkSdAuX4Is8G37-xZ4-7Jgp4jct3FJwP_B14swBRBpnJtaEPyPPvDRNJhItfF_AXMAJE/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction-chemistry+and+creativity.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acetoacetic Ester Synthesis-Organic reaction-chemistry and creativity" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgbCPbQ2SCutEgAlCd2u_fzDAIq2JO2DjomphrJPP8Vpj1YFpueeeF3vYlKlr8f8z_C39Ba1FSgkSdAuX4Is8G37-xZ4-7Jgp4jct3FJwP_B14swBRBpnJtaEPyPPvDRNJhItfF_AXMAJE/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction-chemistry+and+creativity.jpg" title="Acetoacetic Ester Synthesis-Organic reaction-chemistry and creativity" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both;">When α-keto acetic acid is treated with one mole of a base, the methylene group which is more acidic reacts with the base. And the reaction with an alkylation reagent gives alkyl products attached to methylene. When this reaction is repeated in the next step, the other hydrogen can also react to a dialkyl product. The two alkylation agents may be the same or different (R',R'').</div><div class="separator" style="clear: both;"><br /></div><div class="separator" style="clear: both;">β-Keto esters tend to decarboxylate after hydrolysation to β-keto carboxylic acid and heating to give one or two alkyl-substituted ketones, respectively.</div><div class="separator" style="clear: both;"><br /></div><hr align="center" width="80%" /><h3 style="clear: both;"><span style="color: blue; font-size: large;">Mechanism</span></h3>A strong base <b><span style="color: red;">deprotonates</span></b> the dicarbonyl α-carbon. This carbon is preferred over the methyl carbon because the formed enolate is conjugated and thus resonance stabilized. The carbon then undergoes nucleophilic substitution. When heated with aqueous acid, the newly alkylated ester is hydrolyzed to a β-keto acid, which is decarboxylated to form a methyl ketone.<br /><div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjnLBLju_A2PIUpXbzpGVv362UZ4S9nsgAgPUHVrxKgdA23FIwc9DP-m98XZvV0VTlnaG_brcW7J4XdnSf6VEaw3dtdSNeDKjSizEI2CdZF0pVNe48oBb8G9b16KzFl6vGZozIW0swDvJc/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acetoacetic Ester Synthesis-Organic reaction" border="0" height="256" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjnLBLju_A2PIUpXbzpGVv362UZ4S9nsgAgPUHVrxKgdA23FIwc9DP-m98XZvV0VTlnaG_brcW7J4XdnSf6VEaw3dtdSNeDKjSizEI2CdZF0pVNe48oBb8G9b16KzFl6vGZozIW0swDvJc/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" title="Acetoacetic Ester Synthesis-Organic reaction" width="640" /></a></div><br /><b><span style="color: red;">Deprotonates</span></b> :Deprotonation is the removal of a proton (H+) from a molecule, forming the conjugate base. The proton removal decreases positive charge in the molecule and an increases negative charge. Deprotonation usually occurs from the donation of electrons or acceptance of the proton using a base, which forms its conjugate acid.<br /><br /><hr align="center" width="80%" /><br /><h3><span style="color: blue; font-size: large;">Mechanism of Acetoacetic Ester Synthesis</span></h3><b><span style="color: red; font-size: large;">Step 1</span></b><br /><br />In the presence of mild base such as NaOH or NaOEt, the alpha – hydrogen of the beta-keto ester can be abstracted to produce the carbanion which can resonate to form an enolate. Since the enolate can resonate on either side of the ester and the ketone it is more stabilized and hence use of even mild bases can be made for this reaction.<br /><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgeqsqEOZG6udwCpuEqTxW4hm2vgl-pPWi9Rxbcx9QY9jWqe_KIvpNBn1E92yyaYBi3HFjSeyeKiP5Ss2Lb2X0RAVGFAcY8TeG3G97cACd1ouCcuMhhbJqmKee3zV4ODcerv0Kihuw4jOQ/s1600/Mechanism+of+Acetoacetic+Ester+Synthesis.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Mechanism of Acetoacetic Ester Synthesis" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgeqsqEOZG6udwCpuEqTxW4hm2vgl-pPWi9Rxbcx9QY9jWqe_KIvpNBn1E92yyaYBi3HFjSeyeKiP5Ss2Lb2X0RAVGFAcY8TeG3G97cACd1ouCcuMhhbJqmKee3zV4ODcerv0Kihuw4jOQ/s1600/Mechanism+of+Acetoacetic+Ester+Synthesis.jpg" title="Mechanism of Acetoacetic Ester Synthesis" /></a></div><div style="text-align: center;">Abstraction of alpha-proton yields a carbanion which is stabilized by enol formation through resonance on either side of beta keto ester</div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhPY2ZU__ma-fjODfQQMbtzSPUYL0_py3X0r9RdDGVSGS-Jt9ZHXs5lVRV_fiw9bXLYFmf5-eNhR94kjU8KVHr6zSs2lh_KKOv5IJMUZDuWbw4Hf5MMdzPODt9-W2Fn122tRGxGcCDv2mg/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acetoacetic Ester Synthesis-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhPY2ZU__ma-fjODfQQMbtzSPUYL0_py3X0r9RdDGVSGS-Jt9ZHXs5lVRV_fiw9bXLYFmf5-eNhR94kjU8KVHr6zSs2lh_KKOv5IJMUZDuWbw4Hf5MMdzPODt9-W2Fn122tRGxGcCDv2mg/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" title="Acetoacetic Ester Synthesis-Organic reaction" /></a></div><div style="text-align: center;"><br /></div><span style="color: red; font-size: large;"><b>Step 2 and Step 3</b></span><br /><br />The enolate carbanion thus formed is capable of attacking the alkyl halide R-X as the halide is a good leaving group. This yields the mono-alkylated beta-keto ester (i). However, reaction does not stop there. Since the base and alkyl halide are present in the same solution, step 1 and 2 can repeat in step 3 to produce the disubstituted beta-keto ester (ii).<br /><br />Note - For step 2 the carbanion shown below can exist as enolates in resonance structures (as shown above) – hence it can be shown using the illustration below or using enolates but with proper arrows indicating movement of electrons.<br /><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjbDO_XL1h7D5JArHjL4C4SMR8ITmxj_yk08Ux-aG1O09qjm8EE3vj_B5y1QzjUqYxvhkuOlqBm87l-_LgCqiKThpW1fxAP7upHTGeApEUdO05aWaQQBZsRSCMye8yIYanyHVT5rYompD8/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acetoacetic Ester Synthesis-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjbDO_XL1h7D5JArHjL4C4SMR8ITmxj_yk08Ux-aG1O09qjm8EE3vj_B5y1QzjUqYxvhkuOlqBm87l-_LgCqiKThpW1fxAP7upHTGeApEUdO05aWaQQBZsRSCMye8yIYanyHVT5rYompD8/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" title="Acetoacetic Ester Synthesis-Organic reaction" /></a></div><br /><br /><div style="text-align: center;">Attack of the enolate on the alkyl halide (R-X) to yield mono- and di- alkylated beta keto ester</div><div style="text-align: center;"><br /></div><span style="color: red; font-size: large;"><b>Step 4</b></span><br /><br />Upon acidification of the solution the esters can undergo hydrolysis to yield the acid. Note – this reaction can happen with both mono (as shown) as well as di-substituted beta keto ester (not shown).<br /><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh37h_PIQ_y_EjJf1vivwJu50-n5UoCBlt2ZWmapndVrz0nHpMHdsnr-kBCPkH2UExfLIhKCWc44Ye8MQs1co4EP3uzrY4oe-F-UrX9zqfcLYKtPmR9Q6dcQC8HhsWGxOhdhNn33XbSssQ/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acetoacetic Ester Synthesis-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh37h_PIQ_y_EjJf1vivwJu50-n5UoCBlt2ZWmapndVrz0nHpMHdsnr-kBCPkH2UExfLIhKCWc44Ye8MQs1co4EP3uzrY4oe-F-UrX9zqfcLYKtPmR9Q6dcQC8HhsWGxOhdhNn33XbSssQ/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" title="Acetoacetic Ester Synthesis-Organic reaction" /></a></div><br /><span style="color: red; font-size: large;"><b>Step 5</b></span><br /><br />Under acidic conditions and slight heating the beta-keto carboxylate can undergo a loss of carbon dioxide to yield either mono (as shown) or disubstituted (not shown) ketone<br /><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhcucDKIvOW_s22ilcovSHn9_AWJlix51VLKsSOmVcT87-aGvbqfsWrr4HrGRXC0EkOEJsKHIIc4T-FbFx3Jk6iexZ8Ow7VvleCOhh-Lr4yCmLDqnVsqI4dI0iyOaUJpQaTedn9dd9TD6k/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acetoacetic Ester Synthesis-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhcucDKIvOW_s22ilcovSHn9_AWJlix51VLKsSOmVcT87-aGvbqfsWrr4HrGRXC0EkOEJsKHIIc4T-FbFx3Jk6iexZ8Ow7VvleCOhh-Lr4yCmLDqnVsqI4dI0iyOaUJpQaTedn9dd9TD6k/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" title="Acetoacetic Ester Synthesis-Organic reaction" /></a></div><br /><div style="text-align: center;">Under acidic conditions the carboxylic acid can loose one molecule of carbon dioxide to yield the alpha-alkyl ketone.</div><div style="text-align: center;"><br /></div><br /></div><hr align="center" width="80%" /><div><h4><span style="color: blue; font-size: large;"><b>References</b></span></h4><ol><li><a href="http://goo.gl/1TzXY5" target="_blank">Smith, Janice Gorzynski. Organic Chemistry: Second Ed. 2008. pp 905–906</a></li><li><a href="http://pharmaxchange.info/press/2011/02/acetoacetic-ester-synthesis-alkylation-of-enolates/" target="_blank">Acetoacetic Ester Synthesis – Alkylation of Enolates | PharmaXChange.info</a></li></ol><h3><span style="color: blue; font-size: large;">Related Books</span></h3><h4><span style="font-size: large;">1.<a href="http://goo.gl/bovTWx" target="_blank">Organic Chemistry Hardcover . W. Graham Solomons</a></span></h4></div><br /><div class="separator" style="clear: both; text-align: center;"><iframe frameborder="0" marginheight="0" marginwidth="0" scrolling="no" src="//ws-na.amazon-adsystem.com/widgets/q?ServiceVersion=20070822&OneJS=1&Operation=GetAdHtml&MarketPlace=US&source=ac&ref=tf_til&ad_type=product_link&tracking_id=chemistrandcr-20&marketplace=amazon&region=US&placement=1118133579&asins=1118133579&linkId=LIETFKMHHZO4PD5A&show_border=true&link_opens_in_new_window=true" style="height: 240px; width: 120px;"></iframe><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjmL91W5Z16IQu_JSFfS38Tf6-_0orF1SO8tUEceckCfDdm7NlXbJvsVjjwWcFjg-GREi8HWePSks9J7dhZx3usv9419wpwEDgzpgLTsuiASPvpDl1dP2NKyvYywKZIFvb01U3CmGjXfn4/s1600/Organic+Chemistry+Hardcover+T.+W.+Graham+Solomons.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjmL91W5Z16IQu_JSFfS38Tf6-_0orF1SO8tUEceckCfDdm7NlXbJvsVjjwWcFjg-GREi8HWePSks9J7dhZx3usv9419wpwEDgzpgLTsuiASPvpDl1dP2NKyvYywKZIFvb01U3CmGjXfn4/s1600/Organic+Chemistry+Hardcover+T.+W.+Graham+Solomons.jpg" /></a><a href="http://goo.gl/bovTWx" target="_blank"><img alt="buy now" border="0" height="100" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiTQpeTdUkfp4TW2CROEWsG_0LbKbLdJXo7tIxGCeDXSSrpQvB-Qxglp5uGpMI8prT5kEAbr3OItsk2UAck5ABkPHC7WFrZLu10BuEBegqOvYZxTwrffv7GsktKKC-vXrPvIKof9Hg6IFs/s1600/Buy-Now-button.jpg" width="200" /></a></div><span style="text-align: start;"> </span><span style="text-align: start;">Now in a new edition, this book continues its tradition of excellence in teaching and preparing students for success in the organic classroom and beyond. A central theme of the authors' approach to organic chemistry is to emphasize the relationship between structure and reactivity. To accomplish this, the text is organized in a way that combines the most useful features of a functional group approach with one largely based on reaction mechanisms. Emphasizing mechanisms and their common aspects as often as possible, this book shows students what organic chemistry is, how it works, and what it does in living systems and the physical world around us.</span><br /><div class="separator" style="clear: both; text-align: center;"></div><br /><div><h4><span style="color: blue; font-size: large;"> 2.<a href="http://www.amazon.com/gp/product/1118144341/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=1118144341&linkCode=as2&tag=chemistrandcr-20&linkId=PJVFDFQQJC6ZN3NV" target="_blank">Organic Chemistry As a Second Language: Second Semester Topics  David R. Klein</a></span></h4><br /><div class="separator" style="clear: both; text-align: center;"><iframe frameborder="0" marginheight="0" marginwidth="0" scrolling="no" src="//ws-na.amazon-adsystem.com/widgets/q?ServiceVersion=20070822&OneJS=1&Operation=GetAdHtml&MarketPlace=US&source=ac&ref=tf_til&ad_type=product_link&tracking_id=chemistrandcr-20&marketplace=amazon&region=US&placement=1118144341&asins=1118144341&linkId=N5SMFEVAYBLGQQBN&show_border=true&link_opens_in_new_window=true" style="height: 240px; width: 120px;"></iframe><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhP2XbGwccs1RrjEPJ7LiYKP3_QIn7Hea4z3BNtV0nkGYf8w-7cCWYaRlmP34UyJnq8ghzL-EQhDRFPNfa4-h72iSwA8zm5SzeCzotK31biBc7ED0mgrR7UXLhEYd_oDaX9A0VUGRHU35M/s1600/Organic+Chemistry+As+a+Second+Language+Second+Semester+Topics+David+R.+Klein.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhP2XbGwccs1RrjEPJ7LiYKP3_QIn7Hea4z3BNtV0nkGYf8w-7cCWYaRlmP34UyJnq8ghzL-EQhDRFPNfa4-h72iSwA8zm5SzeCzotK31biBc7ED0mgrR7UXLhEYd_oDaX9A0VUGRHU35M/s1600/Organic+Chemistry+As+a+Second+Language+Second+Semester+Topics+David+R.+Klein.jpg" /></a><a href="http://www.amazon.com/gp/product/1118144341/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=1118144341&linkCode=as2&tag=chemistrandcr-20&linkId=PJVFDFQQJC6ZN3NV" target="_blank"><img alt=" Buy Now" border="0" height="100" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiTQpeTdUkfp4TW2CROEWsG_0LbKbLdJXo7tIxGCeDXSSrpQvB-Qxglp5uGpMI8prT5kEAbr3OItsk2UAck5ABkPHC7WFrZLu10BuEBegqOvYZxTwrffv7GsktKKC-vXrPvIKof9Hg6IFs/s1600/Buy-Now-button.jpg" width="200" /></a></div><div style="text-align: left;"><br /></div><br />Readers continue to turn to Klein because it enables them to better understand fundamental principles, solve problems, and focus on what they need to know to succeed. The third edition explores the major principles in the field and explains why they are relevant. It is written in a way that clearly shows the patterns in organic chemistry so that readers can gain a deeper conceptual understanding of the material. Topics are presented clearly in an accessible writing style along with numerous of hands-on problem solving exercises.<br /><div><h4><b><span style="color: blue; font-size: large;">Related Reactions</span></b></h4></div><div><a href="http://www.organic-chemistry.org/namedreactions/knoevenagel-condensation.shtm"><span style="color: purple;">Knoevenagel Condensation</span></a></div><a href="http://www.organic-chemistry.org/namedreactions/malonic-ester-synthesis.shtm"><span style="color: purple;">Malonic Ester Synthesis</span></a><br /><a href="http://www.organic-chemistry.org/synthesis/C1C/carbonyls/alkylations.shtm"><span style="color: purple;">Synthesis of ketones</span></a><br /><br /><span style="color: purple; font-size: large;"><b>Example</b></span><br /><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjYuobrWYZxURDE4wE3YA6MTly1yTA5GmvsIFRzlMUpcEP0AqBWoTTJ1rcbBZcRGcrCBN1W3irb7A8uSChp101Boc1Y9-bbX36slT0Yqf5WL3JxAIY9y9vu1M6YN5SSJiNGDiHZRGgdfVk/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acetoacetic Ester Synthesis-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjYuobrWYZxURDE4wE3YA6MTly1yTA5GmvsIFRzlMUpcEP0AqBWoTTJ1rcbBZcRGcrCBN1W3irb7A8uSChp101Boc1Y9-bbX36slT0Yqf5WL3JxAIY9y9vu1M6YN5SSJiNGDiHZRGgdfVk/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction1.jpg" title="Acetoacetic Ester Synthesis-Organic reaction" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg_oQCbj-Za2uD7JoQP75nQ29sct-lDmAmEbJWegv2jbFuE9uLFNn3vbrD2KEunFYvE7OqwePIIIhLtc_8jecnmDdeYez9KdVMh50U6acoqs-_WEBs7LckrMwM9MYODDwJNiSuUdmsrsVE/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction2.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acetoacetic Ester Synthesis-Organic reaction" border="0" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg_oQCbj-Za2uD7JoQP75nQ29sct-lDmAmEbJWegv2jbFuE9uLFNn3vbrD2KEunFYvE7OqwePIIIhLtc_8jecnmDdeYez9KdVMh50U6acoqs-_WEBs7LckrMwM9MYODDwJNiSuUdmsrsVE/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction2.jpg" title="Acetoacetic Ester Synthesis-Organic reaction" width="382" /></a></div><br /></div>

Acetoacetic Ester Synthesis-Organic reaction

Acetoacetic Ester Synthesis Acetoacetic ester synthesis Acetoacetic ester synthesis is a chemical reaction where ethyl acetoacetate is alkyl...

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Acyloin Condensation-Organic reaction

<h2><span style="font-size: x-large;"><span style="color: blue;">Acyloin Condensation-Name reaction</span></span></h2><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhX9KzVGNcrWYb1JiZjEtFgaCE1sJbz3I0dP7ObQOZLl_t3z1N9iYQyfPuZepMVuzvaoW9yMBo9xI-o2AXU9dJQ4r8DZm04w0egAtJCN6Y2i8Mos5QkmIBtFHrtBZTxaO4sHx1wTQrlbL4/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhX9KzVGNcrWYb1JiZjEtFgaCE1sJbz3I0dP7ObQOZLl_t3z1N9iYQyfPuZepMVuzvaoW9yMBo9xI-o2AXU9dJQ4r8DZm04w0egAtJCN6Y2i8Mos5QkmIBtFHrtBZTxaO4sHx1wTQrlbL4/s1600/Acetoacetic+Ester+Synthesis-Organic+reaction.jpg" title="Acyloin Condensation-Organic reaction" /></a></div><a name="more"></a><br /><div class="separator" style="clear: both; text-align: left;"></div>The acyloin condensation usually involves the reductive dimerization of a carboxylic ester, although acid chlorides and the anhydrides have been used. The reducing agent is in an alkali metal and the product is an ene-diolate. Two gram-atoms of metal are required for each mole of ester with the concomitant formation of a mole of akoxide and one-half mole of the ene-diolate. Oxidation of acyloins to diketoes can be accomplished by a variety of reagents. Acyloins can be reduced to ketones by various modifications of the Clemmenson technique. Under mild conditions the ketone will dominate. This chapter presents a complete picture of both the linear and cyclic acyloin condensation with particular emphasis on developments since 1960. The discussion is closely limited to the acyloin condensation and its modifications<br /><h3><span style="color: red; font-size: large;">Acyloin Condensation</span></h3>Acyloin condensation is a reductive coupling of two carboxylic esters using metallic sodium to yield an α-hydroxyketone, also known as an acyloin<span style="color: blue;"><br /></span><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgc1gBiAyc6_ufwcd-Nn2emF-MEEjOWAsky7P9wFOLAiOO8W6l5tBguRgYPqlDCdDv647G23rqz8D43llRd1HwEt0EHYhfwDeRIL2da_05w817lmgONALOjx1d8UvhfIX-hoW3FZXv3ZV8/s1600/Acyloin+Condensation-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgc1gBiAyc6_ufwcd-Nn2emF-MEEjOWAsky7P9wFOLAiOO8W6l5tBguRgYPqlDCdDv647G23rqz8D43llRd1HwEt0EHYhfwDeRIL2da_05w817lmgONALOjx1d8UvhfIX-hoW3FZXv3ZV8/s1600/Acyloin+Condensation-Organic+reaction.jpg" title="Acyloin Condensation-Organic reaction" /></a></div><div class="separator" style="clear: both; text-align: left;">The bimolecular reductive coupling of carboxylic esters by reaction with metallic sodium in an inert solvent under reflux gives an α-hydroxyketone, which is known as an acyloin. This reaction is favoured when R is an alkyl. With longer alkyl chains, higher boiling solvents can be used. The intramolecular version of this reaction has been used extensively to close rings of different sizes, e.g. paracyclophanes or catenanes.</div><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgV_pg_EOBLY-GkbmzCWWDH9TQ7uPmDpdhstLBat_lL0LGM3AJ3_s0QrbqJTeWlKK0-w7N_OT0a2DFdTGGr2dtp3zBq8gY5C74bg4qfsWeK5FB_4GiS4phsS_RNojYAHOOZfkF2EmH4q9A/s1600/Acyloin+Condensation-Organic+reaction1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgV_pg_EOBLY-GkbmzCWWDH9TQ7uPmDpdhstLBat_lL0LGM3AJ3_s0QrbqJTeWlKK0-w7N_OT0a2DFdTGGr2dtp3zBq8gY5C74bg4qfsWeK5FB_4GiS4phsS_RNojYAHOOZfkF2EmH4q9A/s1600/Acyloin+Condensation-Organic+reaction1.jpg" title="Acyloin Condensation-Organic reaction" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both;">The reaction is carried out in the presence of a proton donor, such as alcohol, simple reduction of the ester to the alcohol takes place (Bouveault-Blanc Reduction).</div><div class="separator" style="clear: both;">The Benzoin Condensation produces similar products, although with aromatic substituents and under different conditions.</div><div class="separator" style="clear: both;">When the acyloin condensation is carried out in the presence of chlorotrimethylsilane, the enediolate intermediate is trapped as the bis-silyl derivative. This can be isolated and subsequently is hydrolysed under acidic condition to the acyloin, which gives a better overall yield.</div><h3 style="clear: both;"><span style="color: blue; font-size: large;">Mechanism of Acyloin Condensation</span></h3><div class="separator" style="clear: both;"><b>The mechanism consists of four steps:</b></div><div class="separator" style="clear: both;">(1) Oxidative ionization of two sodium atoms on the double bond of two ester molecules.</div><div class="separator" style="clear: both;">(2) Free radical coupling between two molecules of the homolytic ester derivative (A Wurtz type coupling). Alkoxy-eliminations in both sides occur, producing a 1,2-diketone.</div><div class="separator" style="clear: both;">(3) Oxidative ionization of two sodium atoms on both diketone double bonds. The sodium enodiolate is formed.</div><div class="separator" style="clear: both;">(4) Neutralization with water to form the enodiol, which tautomerizes to acyloin</div><div class="separator" style="clear: both;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj_qSlWnJhMegr_Ac45TgW3LMoSz5Rao8rQOyVqie4Qt5ZXb2HA4wKjXVlZ7RI5VZIo7gGpXemwGEeERBd3fgkDBtarvz5yZI-M06QN39gaSnyEAptDhcVZ00JTNr-JPsL5p1gonv2YTAQ/s1600/Acyloin+Condensation-Organic+reaction3.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj_qSlWnJhMegr_Ac45TgW3LMoSz5Rao8rQOyVqie4Qt5ZXb2HA4wKjXVlZ7RI5VZIo7gGpXemwGEeERBd3fgkDBtarvz5yZI-M06QN39gaSnyEAptDhcVZ00JTNr-JPsL5p1gonv2YTAQ/s1600/Acyloin+Condensation-Organic+reaction3.jpg" title="Acyloin Condensation-Organic reaction" /></a></div><div class="separator" style="clear: both;"><br /></div><h3 style="clear: both;"><span style="color: red; font-size: large;">Rühlmann-method</span></h3><div class="separator" style="clear: both;">The method according to Rühlmann employs trimethylchlorosilane as a trapping reagent; by this, competing reactions are efficiently subdued. Generally, yields increase considerably. The hydrolytic cleavage of the silylether gives the acyloin. To achieve a mild cleavage methanol can be used in several cases.</div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhEhNLqECW2X9yqUwDLsa1duvKEXBjpQ6rLoTbFD9Sb-41zGUrnm8i5U7Q9JVxHBBTMgTg0PDmvApShFZ_jhmPcQwjSem5DqUnOe-pCbSCHk39IQoo8lE35aw6y82NOX9dDyvLXX-JCBBk/s1600/Acyloin+Condensation-Organic+reaction4.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation-Organic reaction" border="0" height="101" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhEhNLqECW2X9yqUwDLsa1duvKEXBjpQ6rLoTbFD9Sb-41zGUrnm8i5U7Q9JVxHBBTMgTg0PDmvApShFZ_jhmPcQwjSem5DqUnOe-pCbSCHk39IQoo8lE35aw6y82NOX9dDyvLXX-JCBBk/s1600/Acyloin+Condensation-Organic+reaction4.jpg" title="Acyloin Condensation-Organic reaction" width="640" /></a></div><div class="separator" style="clear: both;"><br /></div><div class="separator" style="clear: both;">Usually toluene, dioxane, tetrahydrofuran or acyclic dialkylethers are employed as solvents. Advantageously also N-methyl-morpholine has been used. It allowed in some cases a successful reaction, in which otherwise the reaction failed in less polar media.</div><h3 style="clear: both;"><span style="color: blue; font-size: large;">Related Reactions</span></h3><div class="separator" style="clear: both;">Bouveault-Blanc Reduction</div><div class="separator" style="clear: both;">Synthesis of Acyloins</div><div class="separator" style="clear: both;"><br /></div><h3><span style="color: red; font-size: large;">Books related to Acyloin Condensation</span></h3>1.<a href="http://www.amazon.com/gp/product/0470462590/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=0470462590&linkCode=as2&tag=chemistrandcr-20&linkId=AXABURRWP73O644M" target="_blank">March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure</a><img alt="" border="0" height="1" src="http://ir-na.amazon-adsystem.com/e/ir?t=chemistrandcr-20&l=as2&o=1&a=0470462590" style="border: none !important; margin: 0px !important;" width="1" />Hardcover – April 22, 2013 by Michael B. Smith<br /><div class="separator" style="clear: both; text-align: left;"><a href="http://www.amazon.com/gp/product/0470462590/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=0470462590&linkCode=as2&tag=chemistrandcr-20&linkId=AXABURRWP73O644M" target="_blank"><img alt=" March's Advanced Organic chemistry" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgg6XFnIcvpFvE97IXLFXXb4oYsLJhzq6_vZAK7ufYHkaDS61QPYjrqOhGQHzEJiC1VEKuaODvunfD9HdryvyCktyuJMTxktUWh6lPZB3WLCAUZ8zQMzaPImI1tb6A_WpsWh_JPBhR8vds/s1600/March's%2BAdvanced%2BOrganic%2BChemistry%2BReactions%2C%2BMechanisms%2C%2Band%2BStructur.jpg" title=" March's Advanced Organic chemistry" /></a><a href="http://www.amazon.com/gp/product/0470462590/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=0470462590&linkCode=as2&tag=chemistrandcr-20&linkId=AXABURRWP73O644M" target="_blank"><img alt=" Buy Books" border="0" height="100" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjllXtWmsMU-yXyda8OmdUo5_eBRII02eeAFxjEwX0XRnHPrYB9AoKKLsKVCYQVsbFzcN1NhfcMFIZXVR5doawphFEwpFRdFLqPgDyQbex88sLX1lWtFHjQiI2VqI5dtrprisdcktJQX_A/s1600/Buy-Now-button.jpg" title="Acyloin Condensation-Organic reaction" width="200" /></a></div><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both;">The new, revised and updated 7th edition of March’s Advanced Organic Chemistry clearly explains the theories and examples of organic chemistry, providing the most comprehensive resource about organic chemistry available.</div><div class="separator" style="clear: both;"><br /></div><div class="separator" style="clear: both;">2.<a href="http://www.amazon.com/gp/offer-listing/0080966306/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=0080966306&linkCode=am2&tag=chemistrandcr-20&linkId=DUX2JUSQGXZ3YG3Y" target="_blank">Organic Syntheses Based on Name Reactions, Third Edition: a practical guide to 750 transformations</a><img alt="" border="0" height="1" src="http://ir-na.amazon-adsystem.com/e/ir?t=chemistrandcr-20&l=as2&o=1&a=0080966306" style="border: none !important; margin: 0px !important;" width="1" /></div><div class="separator" style="clear: both; text-align: left;"><a href="http://www.amazon.com/gp/offer-listing/0080966306/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=0080966306&linkCode=am2&tag=chemistrandcr-20&linkId=DUX2JUSQGXZ3YG3Y" target="_blank"><img alt="Organic Syntheses Based on Name Reactions, Third Edition: a practical guide to 750 transformations" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjwnJrouY6it4d5hzTpbPHvRD4XvDhhAPwdWsVt9D2Zxj2GZ1pBGOqE-i57XdjvL2DW1lMBuOLKa6LfZj6_58_DXiMWsUgur3G8eNA4aVdG6ifUsr84G4fpPYKhUSps1HOXoG2dR38ksjY/s1600/Organic+Syntheses+Based+on+Name+Reactions,+Third+Edition+a+practical+guide+to+750+transformations.jpg" title="Organic Syntheses Based on Name Reactions, Third Edition: a practical guide to 750 transformations" /></a><a href="http://www.amazon.com/gp/offer-listing/0080966306/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=0080966306&linkCode=am2&tag=chemistrandcr-20&linkId=DUX2JUSQGXZ3YG3Y" target="_blank"><img alt="Acyloin Condensation-Organic reaction" border="0" height="100" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjllXtWmsMU-yXyda8OmdUo5_eBRII02eeAFxjEwX0XRnHPrYB9AoKKLsKVCYQVsbFzcN1NhfcMFIZXVR5doawphFEwpFRdFLqPgDyQbex88sLX1lWtFHjQiI2VqI5dtrprisdcktJQX_A/s1600/Buy-Now-button.jpg" title="Acyloin Condensation-Organic reaction" width="200" /></a></div><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both; text-align: left;">Organic Syntheses Based on Named Reactions is an indispensable reference companion for chemistry students and researchers. Building on Hassner & Stumer's highly regarded 2e, this new work reviews 750 reactions, with over 100 new stereoselective and regioselective reactions. Each A-Z entry provides a carefully condensed summary of valuable information that a chemist needs to understand and utilize these fundamental reactions in their work, including brief practical details. The book is illustrated with real synthetic examples from the literature and about 3,400 references to the primary literature to aid further reading. Extensive indexes (name, reagent, reaction) and a very useful functional group transformation index help the reader fully navigate this extensive collection of important reactions. With its comprehensive coverage, superb organization and quality of presentation, this long-awaited new edition belongs on the shelf of every organic chemist.</div><div class="separator" style="clear: both;"><br /></div><div class="separator" style="clear: both;">3.<a href="http://www.amazon.com/gp/product/008043259X/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=008043259X&linkCode=as2&tag=chemistrandcr-20&linkId=R54CGTTKYCO53DQV" target="_blank">Organic Syntheses Based on Name Reactions, Volume 22, Second Edition (Tetrahedron Organic Chemistry)</a><img alt="" border="0" height="1" src="http://ir-na.amazon-adsystem.com/e/ir?t=chemistrandcr-20&l=am2&o=1&a=008043259X" style="border: none !important; margin: 0px !important;" width="1" /></div><div class="separator" style="clear: both; text-align: left;"><a href="http://www.amazon.com/gp/product/008043259X/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=008043259X&linkCode=as2&tag=chemistrandcr-20&linkId=R54CGTTKYCO53DQV" target="_blank"><img alt="Organic Syntheses Based on Name Reactions, Volume 22, Second Edition (Tetrahedron Organic Chemistry)" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEh9y3yT-54Qaqg63KYuYyv-LZq8ozRSB_H2M1NS_ICTWCDgYmPN2cZcGKHvg2fNRCUniz-1W7Wkm73Xg2nAfv5cMif6OLPu7r7NFLljb_lIqtFjw4PImIfw4p28WYMEpo-xApjj7HOLybM/s1600/Organic+Syntheses+Based+on+Name+Reactions,+Volume+22,+Second+Edition+(Tetrahedron%2BOrganic%2BChemistry)1.jpg" title="Organic Syntheses Based on Name Reactions, Volume 22, Second Edition (Tetrahedron Organic Chemistry)" /></a><a href="http://www.amazon.com/gp/product/008043259X/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=008043259X&linkCode=as2&tag=chemistrandcr-20&linkId=R54CGTTKYCO53DQV" target="_blank"><img alt="Acyloin Condensation-Organic reaction" border="0" height="100" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjllXtWmsMU-yXyda8OmdUo5_eBRII02eeAFxjEwX0XRnHPrYB9AoKKLsKVCYQVsbFzcN1NhfcMFIZXVR5doawphFEwpFRdFLqPgDyQbex88sLX1lWtFHjQiI2VqI5dtrprisdcktJQX_A/s1600/Buy-Now-button.jpg" title="Acyloin Condensation-Organic reaction" width="200" /></a></div><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both; text-align: left;">Since the publication of "Organic Syntheses Based on Name Reactions and Unnamed Reactions"(Volume 11 in the Tetrahedron Organic Chemistry series), there has been a proliferation of discoveries of name reactions in the field of organic chemistry. Hence, this, the second, revised, edition of the text has focused on the ongoing development in this area of research. The revised title reflects the notion whereby many new reagents and reactions are now being referred to by their names. The inclusion of over 155 new stereoselective and regioselective reagents or reactions including asymmetric syntheses, brings the total to over 540. Features that should be valuable to the reader include over 3000 references, a names index, reagent index, reaction index and a functional group transformation index. The latter of these indexes will allow the reader to search for conversions of one functional group to another and has proved a much utilized tool for the synthetic chemist, searching for pathways to perform synthetic procedures.</div><div class="separator" style="clear: both;"><b style="color: blue; font-size: x-large;">Sample reactions</b></div><div class="separator" style="clear: both;"><b>1.</b><span style="color: #20124d;"><b>This reaction is from the synthesis of Corannulene by Richard G. Lawton</b></span><a href="http://www.synarchive.com/syn/226" rel="" target="_blank"><span style="color: #990000;">(Read more)</span></a></div><div class="separator" style="clear: both;"><span style="color: red;"><br /></span></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj4o5EX-4VlGEZAt_iFWfwZ3OZ2vyH_rj5o5xbEeKLPLiadiTSLxuSoGarJlHnnrpfMemmdS6mo8pued5ufT3hNAxRuJi1nzGyeGTEgaO6YI87zvEubBYIXIvQAAJ39X3GCLXJur-ImgvY/s1600/Acyloin+Condensation-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj4o5EX-4VlGEZAt_iFWfwZ3OZ2vyH_rj5o5xbEeKLPLiadiTSLxuSoGarJlHnnrpfMemmdS6mo8pued5ufT3hNAxRuJi1nzGyeGTEgaO6YI87zvEubBYIXIvQAAJ39X3GCLXJur-ImgvY/s1600/Acyloin+Condensation-Organic+reaction.jpg" title="Acyloin Condensation-Organic reaction" /></a></div><div class="separator" style="clear: both; text-align: left;">2<b>.<span style="color: #20124d;">Acyloin Condensation</span></b></div><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both; text-align: left;">Similar to ester dimerisation, used traditionally to make large rings.</div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjoGXCR90r1NwHISOjW-QW7Rh_nB_WPMRobgEitp51erLfcChpcMJT1EIGAy4LLCI6I0GHAgEPyoB5b3mWj7xbEHAVkYtkr7SJuepnw1URVSlxTWFIOY4IVAjp_kCKktuqdRAKuH96ClqA/s1600/Acyloin+Condensation.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjoGXCR90r1NwHISOjW-QW7Rh_nB_WPMRobgEitp51erLfcChpcMJT1EIGAy4LLCI6I0GHAgEPyoB5b3mWj7xbEHAVkYtkr7SJuepnw1URVSlxTWFIOY4IVAjp_kCKktuqdRAKuH96ClqA/s1600/Acyloin+Condensation.jpg" title="Acyloin Condensation" /></a></div><div class="separator" style="clear: both;"><span style="color: blue;"><br /></span></div><div>Now improved by addition of Me3SiCl which traps the intermediate dianion.</div><div><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjh0VCXfLgc729Q-EO96iGNJv4EhB6OxMj-EtLJpok0TEdnFkZtKVNMVA9iY6Mmdj3xsmlN-9XrWoahb53dB3l1ecNRMwVRXI32oT7SPTEViZU1DzdM937W3fKfTMhDLHO-BBTe2cDeY7A/s1600/Acyloin+Condensation1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation-Organic reaction" border="0" height="78" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjh0VCXfLgc729Q-EO96iGNJv4EhB6OxMj-EtLJpok0TEdnFkZtKVNMVA9iY6Mmdj3xsmlN-9XrWoahb53dB3l1ecNRMwVRXI32oT7SPTEViZU1DzdM937W3fKfTMhDLHO-BBTe2cDeY7A/s1600/Acyloin+Condensation1.jpg" title="Acyloin Condensation-Organic reaction" width="640" /></a></div><div><br /></div><blockquote class="tr_bq"><a href="http://www.uea.ac.uk/~c286/notes/retrosynthesis.htm" target="_blank">http://www.uea.ac.uk/~c286/notes/retrosynthesis.htm</a></blockquote>3.<b><span style="color: #20124d;">Acyloin Condensation examples </span><span style="color: red;">(<a href="http://p.pw/badHdQ" rel="nofollow" target="_blank">More</a>)</span></b><br /><b><span style="color: #20124d;"><br /></span></b>Esters undergo a dimerization reduction reaction that is called an acyloin condensation. This name comes from the common name of the simplest reaction product, acyloin, which is an α-hydroxy<br />ketone. The initial product of the reaction is the disodium salt of an enediol. To form the acyloin product, the disodium salt hydrolyzes in aqueous acid.<br /><br /><div class="separator" style="clear: both; text-align: center;"></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgmqv5EGjuDzTdrH681qDOzM7-es0xpRnjwEUl32I4CvmPJtO4lcwWXlHNCnqVLxzbh0VQr3Fi6EQEXulR5Z9PpYv9D7ThTnIp5yC-9WMA33ArXvbrirJk4-4wZVzlEM9eUPCVHF_0_wbY/s1600/Acyloin+Condensation-Organic+reaction1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgmqv5EGjuDzTdrH681qDOzM7-es0xpRnjwEUl32I4CvmPJtO4lcwWXlHNCnqVLxzbh0VQr3Fi6EQEXulR5Z9PpYv9D7ThTnIp5yC-9WMA33ArXvbrirJk4-4wZVzlEM9eUPCVHF_0_wbY/s1600/Acyloin+Condensation-Organic+reaction1.jpg" title="Acyloin Condensation-Organic reaction" /></a></div><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both;"><b>The acyloin condensation</b> is one of the best methods to use when synthesizing medium to large sized rings. The synthesis begins with the metal and solvent. Then the diester substrate is added very</div><div class="separator" style="clear: both;">slowly. This procedure allows the two ends of the substrate to find each other in an intramolecular reaction, while it suppresses any intermolecular reactions.</div><div class="separator" style="clear: both;"><br /></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjWYJW7KwrngYAgUhDFmVzme_L0_OCHZLaJ50xKsd6qnLLYEnxLPCeixFE53fbU2NggxsViDj1OdGxYmMSwuXSU3l4KgCP_ftka9GoDjh0BJayTc-Uu_YzNAcWyvNnu9DufsEFzlK3YOoQ/s1600/Acyloin+Condensation-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Acyloin Condensation-Organic reaction" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjWYJW7KwrngYAgUhDFmVzme_L0_OCHZLaJ50xKsd6qnLLYEnxLPCeixFE53fbU2NggxsViDj1OdGxYmMSwuXSU3l4KgCP_ftka9GoDjh0BJayTc-Uu_YzNAcWyvNnu9DufsEFzlK3YOoQ/s1600/Acyloin+Condensation-Organic+reaction.jpg" title="Acyloin Condensation-Organic reaction" /></a></div><div class="separator" style="clear: both; text-align: center;"><br /></div><div class="separator" style="clear: both; text-align: left;">4.<b>Preparation of cyclic acyloins</b></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhRpHPpc68gK0zAxZRxKiRn54lVWabMwR_XoLK6mbGpiWUvATA5xjHc7md_Jw1Ey_iM0pkHAULSY_6W7Ao0iw5thU3-6Ty2i1ZQqPffRkF-GBMEF0SVFcJdeEfL2goIomC6iDYqXolUY_c/s1600/Acyloin+Condensation-Organic+reaction.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Preparation of cyclic acyloins" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhRpHPpc68gK0zAxZRxKiRn54lVWabMwR_XoLK6mbGpiWUvATA5xjHc7md_Jw1Ey_iM0pkHAULSY_6W7Ao0iw5thU3-6Ty2i1ZQqPffRkF-GBMEF0SVFcJdeEfL2goIomC6iDYqXolUY_c/s1600/Acyloin+Condensation-Organic+reaction.jpg" title="Preparation of cyclic acyloins" /></a></div><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both; text-align: center;"></div><div class="separator" style="clear: both;"><br /></div><br /><span style="color: red; font-size: large;">References</span><br /><ol><li>Bouveault, L., and R. Loquin (1905). "Action du sodium sur les éthers des acides monobasiques à fonction simple de la série grasse". Compt. Rend. 140: 1593–1595.</li><li>Finley, K. T. (1964). "The Acyloin Condensation as a Cyclization Method". Chemical Reviews 64 (5): 573–589. doi:10.1021/cr60231a004.</li><li>Bloomfield, J. J.; Owsley, D. C.; Nelke, J. M. Org. React. 1976, 23.Acyloin condensation</li><li>Rühlmann K. (1971). "Die Umsetzung von Carbonsäureestern mit Natrium in Gegenwart von Trimethylchlorsilan" [Reaction of carboxylic acid esters with sodium in the presence of trimethylchlorosilane Synthesis 1971</li><li><a href="http://p.pw/badHbZ" rel="nofollow" target="_blank">Acyloin Ester Condensation(File PDF)</a></li><li><a href="http://p.pw/badHcn" rel="nofollow" target="_blank">Chemistry 144 Organic Synthesis M. E. Jung</a></li></ol><div><h4><span style="color: red; font-size: large;">APPLICATION</span></h4><div><ol><li><b><span style="color: blue;">Preparation of cyclic acyloins </span></b>– This condensation has been used for preparation cyclic acyloins. Long chain dicarboxylic esters have been converted to large ring compounds without the use of dilution technique. It is used best for closing rings of ten members or more.</li><li><b><span style="color: blue;">Preparation of CATENANE </span></b>– CATENANE is a very interesting & unique compound with interlocking rings. It is formed when acyloin condensation was employed for ring closure with esters of 34-carbon dicarboxylic acids.</li></ol></div></div>

Acyloin Condensation-Organic reaction

Acyloin Condensation-Name reaction The acyloin condensation usually involves the reductive dimerization of a carboxylic ester, although acid...

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Chemistry lesson 2: OXIDATIONS

<h2 style="text-align: center;"><span style="font-size: x-large;"><span style="color: blue;">Oxidations<a name="more"></a></span></span><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhyblnLQEo4bKT1bShXHFau_uwWsFWsZ9XVjtACdx7aZ_qYZg6CFgQ9lw7sHmCbBr9Kjtlk-hffBQK3FwvA4VfovGU3xjXGHJ7cxMEuuJ_KNHMantRxLYuk7v2CUXgrBs9RNLHVJXARofY/s1600/Oxidations.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em; text-align: center;"><img alt=" Oxidations" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhyblnLQEo4bKT1bShXHFau_uwWsFWsZ9XVjtACdx7aZ_qYZg6CFgQ9lw7sHmCbBr9Kjtlk-hffBQK3FwvA4VfovGU3xjXGHJ7cxMEuuJ_KNHMantRxLYuk7v2CUXgrBs9RNLHVJXARofY/s1600/Oxidations.jpg" title=" Oxidations" /></a></h2><h3><span style="color: purple;">Oxidations </span><span style="color: purple;">Carey & Sundberg</span></h3>I. Metal Based Reagents<br />1. Chromium Reagents<br />2. Manganese Rgts.<br />3. Silver<br />4. Ruthenium<br />5. other metals<br />II Non-Metal Based Reagents<br />1. Activated DMSO<br />2. Peroxides and Peracids<br />3. Oxygen/ ozone<br />4. others<br />III. Epoxidations<br /><br /><div class="separator" style="clear: both; text-align: center;"></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjK-Ec7VwvG-QGlwR0cXQhMmB-c3zVi6zE8ULwfVjsBhDdTVKlaoCLjuft-AC_cSFPrAoMfoxPhDwoRP2IhP5dna-kFKQR_6BNgecg0XYIpuYXB5RCZy2MbWbEKrbzOubhM8Sz5b3FWgW8/s1600/download_opt.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Chemistry lesson 2: OXIDATIONS" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjK-Ec7VwvG-QGlwR0cXQhMmB-c3zVi6zE8ULwfVjsBhDdTVKlaoCLjuft-AC_cSFPrAoMfoxPhDwoRP2IhP5dna-kFKQR_6BNgecg0XYIpuYXB5RCZy2MbWbEKrbzOubhM8Sz5b3FWgW8/s1600/download_opt.jpg" title="Chemistry lesson 2: OXIDATIONS" /></a></div><div class="separator" style="clear: both; text-align: center;"><a href="https://www.mediafire.com/?ey124yp3q6cbd21" rel="nofollow" target="_blank">https://www.mediafire.com/?ey124yp3q6cbd21</a></div><br /><iframe frameborder="0" src="https://googledrive.com/host/0B1i9PwsI0eqWNFczbnJFUnFlb2M" style="height: 550px; width: 640px;"></iframe>

Chemistry lesson 2: OXIDATIONS

Oxidations Oxidations  Carey & Sundberg I. Metal Based Reagents 1. Chromium Reagents 2. Manganese Rgts. 3. Silver 4. Ruthenium 5. other ...

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Chemistry lesson: Advanced Organic Chemistry -Lesson 106

<h2 style="text-align: center;"><span style="font-size: x-large;"><span style="color: red;">Chemistry 106:</span> <span style="color: blue;">Advanced Organic Chemistry<a name="more"></a></span></span></h2><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgjZtLskGBcOs7ZV0dDs4O8RbxVSFERuEJ1hmqeVup60fJPvXDO_DAYn2fddccRTmCjpugo3ziTNEXy0qE87_9nGC5vrb2qfpiNJCMP8wuy02twdQbqwiacdgorBReKP-n7a2xoRj43lM8/s1600/Chemistry+lesson+Advanced+Organic+Chemistry+-Lesson+106.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Chemistry lesson Advanced Organic Chemistry -Lesson 106" border="0" height="478" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgjZtLskGBcOs7ZV0dDs4O8RbxVSFERuEJ1hmqeVup60fJPvXDO_DAYn2fddccRTmCjpugo3ziTNEXy0qE87_9nGC5vrb2qfpiNJCMP8wuy02twdQbqwiacdgorBReKP-n7a2xoRj43lM8/s1600/Chemistry+lesson+Advanced+Organic+Chemistry+-Lesson+106.jpg" title="Chemistry lesson Advanced Organic Chemistry -Lesson 106" width="640" /></a></div><div><span style="font-size: x-large;"><span style="color: blue;"></span></span><br /><a href="https://www.blogger.com/null" name="more"></a></div><div><ol><li><span style="color: purple;"><span style="font-size: large;">Lecture 1 - Energy and Reactivity</span></span></li><li><span style="color: purple;"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><a href="http://www.mediafire.com/view/19u1m5dj80dctvj/1_-_Energy_and_Reactivity.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/19u1m5dj80dctvj/1_-_Energy_and_Reactivity.pdf</a><br /> <div class="separator" style="clear: both; text-align: center;"><br /></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 2 - Bonding</span><br /><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/view/ojcgvudl8da78cj/2_-_Bonding.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/ojcgvudl8da78cj/2_-_Bonding.pdf</a></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 3 - Pericyclic Reactions</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/view/s1r6zfx541qma94/3_-_Pericyclic_Reactions.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/s1r6zfx541qma94/3_-_Pericyclic_Reactions.pdf</a></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 6 - Acyclic Conformational Analysis</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;">http://www.mediafire.com/view/tcqp9q5zx7r63cc/6_-_Acyclic_Conformational_Analysis.pdf</div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 7 - Acyclic Stereocontrol</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/view/28v5cbb0aejlfnr/7_-_Acyclic_Stereocontrol.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/28v5cbb0aejlfnr/7_-_Acyclic_Stereocontrol.pdf</a></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 8 - Aldol Reaction</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/view/3pyu577xyxbuycu/8_-_Aldol_Reaction.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/3pyu577xyxbuycu/8_-_Aldol_Reaction.pdf</a></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 9 - Small Ring Conformational Analysis</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/view/qblaooxb1hqc9au/10_-_Computational_Chemistry_I.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/qblaooxb1hqc9au/10_-_Computational_Chemistry_I.pdf</a></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 10 - Computational Chemistry I</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/view/qblaooxb1hqc9au/10_-_Computational_Chemistry_I.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/qblaooxb1hqc9au/10_-_Computational_Chemistry_I.pdf</a></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 11 - Computational Chemistry II</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;">http://www.mediafire.com/view/rqxugz7h5k376a4/11_-_Computational_Chemistry_II.pdf</div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 13 - Nucleophilic Substitution</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/view/unfk45wukwnl4h2/13_-_Nucleophilic_Substitution.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/unfk45wukwnl4h2/13_-_Nucleophilic_Substitution.pdf</a></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 14 - NMR I</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/download/8ao6twscn03hoh3/14+-+NMR+I.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/download/8ao6twscn03hoh3/14+-+NMR+I.pdf</a></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 14 Supplement - Hoye's Method</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/download/8p19mafq8jju7qz/Hoye_s+Method.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/download/8p19mafq8jju7qz/Hoye_s+Method.pdf</a></div><div style="text-align: center;"><br /></div></span></li><li><span style="color: purple;"><span style="font-size: large;">Lecture 15 - NMR II</span><div style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="chemistry and creativity" border="0" height="82" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgAz_0zWoWdkH-L1uy5TF8vERf3irYRurdC3TdpZbfxsN1JiZuorKJibDsqQtxkx0mDk2JDwM0i5VvnXKZh9rdNUH4EZH0hUYS9lVjeI6gT3TgBd04mFi1e_2uyA1TPLQ_YqxKro1nKSaQ/s1600/download.jpg" title="chemistry and creativity" width="200" /></a></div><div style="text-align: center;"><a href="http://www.mediafire.com/view/zdbuubb688hbtcj/15_-_NMR_II.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/view/zdbuubb688hbtcj/15_-_NMR_II.pdf</a></div></span></li></ol></div>

Chemistry lesson: Advanced Organic Chemistry -Lesson 106

Chemistry 106: Advanced Organic Chemistry Lecture 1 - Energy and Reactivity http://www.mediafire.com/view/19u1m5dj80dctvj/1_-_Energy_and_Re...

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