Advanced Practical Medicinal Chemistry

<h2 style="text-align: center;"><span style="font-size: x-large;"><span style="color: red;">Chemistry and creativity</span>: <span style="color: blue;">Advanced Practical Medicinal Chemistry</span></span></h2><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgUKpHiXKEsc6ckYChhfMsc2VXixreJ7q6JSRnovJ0pLazwqC5tpMBeteobzmS97-VGCIEMbezOas_DXJVW_0SU6ddTQdjjx9D30dX0lTMpee-d6CQcYouKBhL-RdODu2STNRYZCpAP0XU/s1600/Advanced+Practical+Medicinal+Chemistry_opt.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Advanced Practical Medicinal Chemistry-Free Medical books" border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgUKpHiXKEsc6ckYChhfMsc2VXixreJ7q6JSRnovJ0pLazwqC5tpMBeteobzmS97-VGCIEMbezOas_DXJVW_0SU6ddTQdjjx9D30dX0lTMpee-d6CQcYouKBhL-RdODu2STNRYZCpAP0XU/s1600/Advanced+Practical+Medicinal+Chemistry_opt.jpg" title="Advanced Practical Medicinal Chemistry-Free Medical books" width="237" /></a></div><a name="more"></a><br /><blockquote class="tr_bq"><a href="https://www.facebook.com/Chemistry.and.pharmacy?ref=hl" target="_blank">https://www.facebook.com/Chemistry.and.pharmacy?ref=hl</a></blockquote><h3>Advanced Practical Medicinal Chemistry</h3>The ‘art and skill’ for the preparation of ‘newer drug molecules’ is a pivotal creative and an<br />exceptionally great intellectual exercise that essentially serves as a fulcrum to plethora of specificareas of scientific research, ranging from the most applied to the most academic. Accordingly,<br />the <b>medicinal chemist</b>, <b>organic chemist</b>, <b>biologist</b>, <b>pharmacologist</b>, <b>biochemist</b>,<br /><b>biotechnologist</b>, <b>phytochemist</b>, g<b>enetic engineer</b>, <b>materials scientist</b>, and polymer scientist, in<br />an university or an industry, all must have genuinely encountered with the most challenging<br />and intricate task of performing a reaction ultimately leading to an entirely new organic preparation<br />exhibiting certain specific actions on the biological system to combat diseases in the<br />ailing human beings.<br />Invariably, the wonderful ‘magic’ of modern <b>organic synthesis</b>, based on host of documented<br />theories, hypothesis, <b>organic </b>name reactions (ONRs) amalgamated with logistic, scientific<br />and assertive reaction mechanism(s), in fact, genuinely paved the way of complicated, notso-<br />easy, cumbersome course of reactions much simpler and understandable.<br />The advent of ever-more sophisticated and many supportive modern analytical techniques,<br />such as : UV, IR, NMR, MS, ORD, CD, AAS, FES, GC, HPLC and the hyphenated<br />techniques as well, have tremendously enhanced the confidence of medicinal <b>chemists </b>to such a<br />magnitude as to maximize both the chances of success rate and probability factor.<br />Besides, the use of <b>organic </b>and <b>inorganic chemicals</b> employed as reactants, catalysts,<br />medium of reaction, purifying substances etc., are not only harmful but also hazardous in nature.<br />Nevertheless, the various conditionalities of critical and specific reactions are sometimes<br />articulated and spelled out so meticulously that one has to follow them just like ‘gospel truth’,<br />to accomplish the right <b>synthesis</b>, and hence, the right product.<br />It is, however, pertinent to mention here that the UG and PG students, associated with<br />the myth and reality of ‘drug synthesis’ should make an honest attempt to carry out a particular<br />synthesis of a drug substance with a most tried and tested methodical, scientific and rational<br />approach, so that one may get reproducible results under a particular reaction in a seamless<br />manner.<br />The copious volumes of <b>textbooks</b>, scientific research journals, monographs, review articles<br />on related topics like : <b>organic chemistry</b> of drug <b>synthesis</b>, <b>chiral chemistry</b>, drug design,<br />principles of <b>medicinal chemistry</b>, <b>organic medicinal and pharmaceutical chemistry</b>, and <b>medicinal<br />chemistry</b> provide ample evidence and scope to suggest that the comprehensive in-depth<br />knowledge together with utmost specialized state-of-the-art know-how of the various techniques<br />is an absolute necessity and basic requirement to have a real understanding with regard to the<br />practical aspects of ‘<b>Medicinal Chemistry</b>’.<br />In ‘<b>Advanced Practical Medicinal Chemistry</b>’, an attempt has been made to stress<br />the much needed requirement of both undergraduate and graduate students specializing in the<br />field of <b>Pharmaceutical Chemistry</b> to learn how to synthesize ‘drugs’ in the laboratory. Unfortunately,<br />the common available <b>textbooks </b>ordinarily referred to by the Pharmacy Students<br />mostly deal with the synthesis of pure ‘organic compounds’ ; and hence, do not provide the<br />real and much needed subject matter relevant to a budding ‘Medicinal Chemist’.<br />The ‘<b>Advanced Practical Medicinal Chemistry</b>’ comprises of four major chapters<br />that are intimately associated with specific emphasis on the synthesis of a broad range of some<br />typical and selected ‘drugs’ commonly found in the therapeutic armamentarium.<br />Chapter-1 deals with ‘Safety in a Chemical Laboratory‘. It consists of various aspects,<br />namely : guard against personal safety ; conduct in a <b>chemistry laboratory</b> ; neatness and cleanliness<br />; after-hours working ; guidelines for accident or injury ; storage of chemicals/reagents in<br />a chemical laboratory ; glass ware ; waste disposal ; an ideal chemistry laboratory ; and toxicity<br />and hazards of chemicals/reagents.<br />Chapter-2 consists of ‘Drug Synthesis’. First, aspect being—‘Conceptualization of a Synthesis‘<br />viz., prime considerations in designing synthesis ; the Synthon Approach ; reaction<br />specificity. Secondly, Reaction Variants, viz., structural variants ; interchangeability of functional<br />moiety ; selectivity in reactions ; protection of functional moieties ; elimination of functional<br />moieties ; annealation reactions ; fragmentation reactions. Thirdly, <b>Stereochemistry</b>, viz.,<br />nucleophilic substitutions (SN2), ionic additions to C-C double bonds ; catalytic hydrogenation ;<br />acid or base promoted enolization of compounds, reductions of cyclohexane ; and cycloadditions.<br />Chapter-3 comprises of ‘Performing the Reactions’. The wide range of latest laboratory<br />techniques invariably employed in a reasonably well equipped chemical research laboratory or<br />a chemical laboratory for actually performing the specifically desired reactions and other equally<br />important operational measures have been dealt with in an explicit and lucid manner. The<br />various aspects included in this chapter are, namely : solvent stills (with continuous still collecting<br />head)-reactions performed at elevated temperatures-large scale reaction and slow addition<br />of reagents-low temperature reactions-reaction above room temperature using a condensermechanical<br />stirrer-mechanical shaker-crystallization at low temperature-distillation under reduced<br />pressure-small scale distillation-performing the reaction, and -photolysis.<br />Chapter-4 i.e., the last chapter, has been exclusively devoted to—‘Synthesis of Medicinal<br />Compounds’ which vary in length from the single-stage reaction to the multi-stage or projecttype<br />synthesis. In fact, it is the backbone of the present textbook and specially designed to<br />inculcate the sense of creativity, learning the art of synthesis, and above all inject the spirit of<br />zeal and enthusiasm amongst the ‘medicinal chemists’ to tackle most synthesis-related problems<br />with great ease, confidence and fervour. It embraces ‘three’ specific areas of interest<br />confined to the ‘synthesis of drugs’, such as :<br />(a) Types of Chemical Reactions e.g., acetylation methods-benzoylation methodssulphonation<br />methods-bromination methods-condensation reactions ; and diazotization and<br />coupling reactions ;<br />(b) Organic Name Reactions (ONRs) e.g., Bart reaction-Diel’s-Alder reaction-Friedel-<br />Craft’s reaction-Fries reaction-Grignard reaction-Hoesch reaction-Perkin reaction-Mannich<br />reaction-Michael reaction, and Reimer-Tieman reaction ;<br />(c) Selected Medicinal Compounds : It includes the synthesis of forty selected medicinal<br />compounds having a wide variety of therapeutic action(s).<br />An intensive and extensive care has been exercised painstakingly and meticulously to<br />discuss in details each and every medicinal compound under the above mentioned three categories<br />i.e., (a) through (c) in a particular original style of presentation that essentially includes :<br />( viii )<br />chemical structure-synonym(s)/chemical name(s)-theory-chemicals required-procedure-precautions-<br />recrystallization-theoretical yield/practical yield-physical parameters-uses, and -questions<br />for viva-voce.<br />A subtle, but no less profound effect of this completely new approach as given in the<br />‘<b>Advanced Practical Medicinal Chemistry</b>’ comprising of syntheses totalling eighty selected<br />‘drug substances’ would not only benefit the undergraduate and graduate students in<br /><b>Pharmaceutical Chemistry</b> in Indian Universities and other developing countries as well, but<br />also go a along way to help the esteemed teachers involved in the handling of such courses who<br />always genuinely felt the dire necessity of such a compilation for the ‘academics’ in particular.<br />The ‘medicinal chemists’ involved in ‘Bulk Drug Manufacturing Operations’ may also<br />find this presentation as a handy reference book in the domain of their ever expanding and<br />demanding profession.<br />In case, the above outlined objectives have been duly achieved, actual users of this textbook<br />must be able to accomplish their synthetic problems with greater ease and confidence.<br />Synthesis of ‘Medicinal Compounds’ is not only satisfying but also exciting, and provides an<br />ample opportunity to explore an individual’s inherent talent and enormous strength of ‘real<br />creativities’<br /><br /><span style="color: red; font-size: large;">Ashutosh Kar</span><br /><div><h3>Advanced Practical Medicinal Chemistry</h3></div><div><div>1.1. Introduction 1</div><div>1.2. Guard Against Personal Safety 2</div><div>1.2.1. Protective Coat 2</div><div>1.2.2. Protection for Eyes 2</div><div>1.2.3. Conduct in a <b>Chemistry </b>Laboratory 3</div><div>1.2.4. Neatness and Cleanliness 3</div><div>1.2.5. After-Hours Working 6</div><div>1.2.6. Guidelines for Accident or Injury 6</div><div>1.2.7. Storage of Chemicals/Reagents in a Chemical Laboratory 7</div><div>1.2.8. Glassware 8</div><div>1.2.9. Waste Disposal 9</div><div>1.2.10. An Ideal <b>Chemistry </b>Laboratory 9</div><div>1.2.11. Toxicity and Hazards of Chemicals Reagents 10</div><div>2.1. Introduction 15</div><div>2.2. Conceptualization of a Synthesis 15</div><div>2.2.1. Prime Considerations in Designing Synthesis 16</div><div>2.2.2. The Synthon Approach 17</div><div>2.2.3. The Retro-Synthetic Approach 18</div><div>2.2.4. Materials Required 19</div><div>2.2.5. Reaction Specificity 20</div><div>2.2.6. Purity and Yield 21</div><div>2.3. Reaction Variants 21</div><div>2.3.1. Structural Variants 21</div><div>2.3.2. Interchangeability of Functional Moiety 22</div><div>2.3.3. Selectivity in Reactions 27</div><div>2.3.4. Protection of Functional Moieties 28</div><div>2.3.5. Elimination of Functional Moieties 31</div><div>2.3.6. Annelation Reactions 32</div><div>2.3.7. Fragmentation Reactions 34</div><div>2.4. <b>Stereochemistry </b>37</div><div>2.4.1. The Chiral Centre 37</div><div>2.5. Summary 43</div><div>3.1. Introduction 45</div><div>I. Solvent Stills 46</div><div>II. Reactions Performed at Elevated Temperatures 49</div><div>III. Large Scale Reactions and Slow Addition of Reagents 50</div><div>IV. Low Temperature Reactions 50</div><div>V. Reactions above Room Temperature Using a Condenser 54</div><div>VI. Mechanical Stirrers 56</div><div>VII. Mechanical Shakers 57</div><div>VIII. Sonication 58</div><div>IX. Crystallization at Low Temperature 59</div><div>X. Distillation Under Reduced Pressure 60</div><div>XI. Small Scale Distillation 62</div><div>XII. Performing the Reaction 62</div><div>XIII. Photolysis 64 </div><div>4.1. Acetylation Methods 67</div><div>4.1.1. Introduction 67</div><div>4.1.2. Synthesis of Medicinal Compounds 71</div><div>4.1.2.1. Acetanilide 71</div><div>4.1.2.2. Aspririn 75</div><div>4.1.2.3. Acetylacetone 80</div><div>4.1.2.4. Phenacetein 83</div><div>4.1.2.5. Acetylcysteine 86</div><div>4.1.2.6. Paracetamol 88</div><div>4.2. Benzoylation Methods 90</div><div>4.2.1. Introduction 90</div><div>4.2.2. Synthesis of Medicinal Compounds 93</div><div>4.2.2.1. Benzoyl Glycine 93</div><div>4.2.2.2. N-Benzoyl-beta-alanine 95</div><div>4.2.2.3. Flavone 97</div><div>4.2.2.4. Benzoyl Peroxide 100</div><div>4.2.2.5. Benzoyl Benzoate 103</div><div>4.3. Sulphonylation Methods 105</div><div>4.3.1. Introduction 105</div><div>4.3.1.1. Similarity with Benzoylation 106</div><div>4.3.1.2. Dissimilarity with Benzoylation 106</div><div>4.3.2. Synthesis of Medicinal Compounds 107</div><div>4.3.2.1. Dichloramine-T 108</div><div>4.3.2.2. Chloramine-T 112</div><div>4.4. Bromination Methods 115</div><div>4.4.1. Introduction 115</div><div>4.4.1.1. Mechanism of Bromination 115</div><div>( xiii )</div><div>4.4.2. Synthesis of Medicinal Compounds 116</div><div>4.4.2.1. para-Bromoacetanilide 116</div><div>4.4.2.2. para-Bromophenol 118</div><div>4.4.2.3. 2′, 4′, 5′, 7′-Tetrabromofluorescein 121</div><div>4.5. Condensation Reactions 125</div><div>4.5.1. Claisen Condensation 125</div><div>4.5.2. Sorbic Acid 128</div><div>4.5.3. Pechman Condensation 130</div><div>4.6. Diazotization and Coupling Reactions 133</div><div>4.6.1. Phenyl-azo-beta-naphthol 136</div><div>4.6.2. 5-Diazouracil 139</div><div>4.6.3. Dimethyl-p-phenylenediamine 140</div><div>4.7. Organic Name Reactions (ONRs) 145</div><div>4.7.1. Bart Reaction 145</div><div>4.7.1.1. Phenylarsonic Acid 146</div><div>4.7.2. Diels-Alder Reaction 149</div><div>4.7.2.1. 9, 10-Dihydroanthracene-9, 10-endo-αβ-succinic anhydride 150</div><div>4.7.3. Friedal-Craft’s Reaction 150</div><div>4.7.3.1. Acetophenone 153</div><div>4.7.3.2. p-Methylacetophenone 158</div><div>4.7.3.3. Anthrone 160</div><div>4.7.4. Frie’s Reaction 165</div><div>4.7.4.1. p-Hydroxypropiophenone 166</div><div>4.7.5. Grignard Reaction 168</div><div>4.7.5.1. Benzoic acid 169</div><div>4.7.5.2. Triphenylcarbinol 172</div><div>4.7.6. Hoesch Reaction (or Houben-Hoesch Reaction) 175</div><div>4.7.6.1. Floropione 176</div><div>4.7.6.2. Resacetophenone 179</div><div>4.7.7. Perkin Reaction 181</div><div>4.7.7.1. Cinnamic acid 182</div><div>4.7.7.2. Coumarin 185</div><div>4.7.8. Mannich Reaction 187</div><div>4.7.8.1. Metamfepramone 188</div><div>4.7.8.2. Garmine 190</div><div>4.7.9. Michael Reaction 192</div><div>4.7.9.1. 5, 5-Dimethyl-1, 3-cyclohexanedione 193</div><div>4.7.9.2. Tricarballylic Acid 195</div><div>4.7.10. Reiner-Tiemann Reaction 200</div><div>4.7.10.1. para-Anisaldehyde 201</div><div>4.7.10.2. Salicylaldehyde 203</div><div>4.8. Selected Medicinal Compounds 206</div><div>4.8.1. Acyclovir 207</div><div>4.8.2. Acetaminophen 209</div><div>4.8.3. Busulfan 211</div><div>4.8.4. Buthiazide 213</div><div>4.8.5. Benzocaine 216</div><div>4.8.6. Coumarin-3-carboxylic acid 221</div><div>4.8.7. Chlormezanone 226</div><div>4.8.8. Chlorpropamide 229</div><div>4.8.9. Clotrimazole 231</div><div>4.8.10. Diazoxide 233</div><div>4.8.11. Diclofenac Sodium 236</div><div>4.8.12. 5, 5-Diphenyl Hydantoin (Phenytoin) Sodium 239</div><div>4.8.13. Ethamivan 242</div><div>4.8.14. Etofylline Clofibrate 243</div><div>4.8.15. Fenbufen 246</div><div>4.8.16. Flumethiazide 248</div><div>4.8.17. Guaifensin 250</div><div>4.8.18. Guanethidine Sulphate 252</div><div>4.8.19. Haloprogin 255</div><div>4.8.20. Hepronicate 257</div><div>4.8.21. Indomethacin 259</div><div>4.8.22. Isocarboxazid 262</div><div>4.8.23. Isoniazid 264</div><div>4.8.24. Ketotifen 266</div><div>4.8.25. Loxapine 269</div><div>4.8.26. Mazindol 272</div><div>4.8.27. Methyldopa 275</div><div>4.8.28. Metronidazole 277</div><div>4.8.29. Naproxen 279</div><div>4.8.30. Niclosamide 281</div><div>4.8.31. Oxaceprol 283</div><div>4.8.32. Oxyfedrine 285</div><div>4.8.33. Phensuximide 286</div><div>4.8.34. Povidone Iodine 288</div><div>4.8.35. Ritodrine 290</div><div>4.8.36. Simethicone 292</div><div>4.8.37. Ticrynafen 294</div><div>4.8.38. Tocainide 298</div><div>4.8.39. Trimethoprim 300</div><div>4.8.40. Zipeprol 304</div></div><div class="separator" style="clear: both; text-align: center;"></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjK-Ec7VwvG-QGlwR0cXQhMmB-c3zVi6zE8ULwfVjsBhDdTVKlaoCLjuft-AC_cSFPrAoMfoxPhDwoRP2IhP5dna-kFKQR_6BNgecg0XYIpuYXB5RCZy2MbWbEKrbzOubhM8Sz5b3FWgW8/s1600/download_opt.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Advanced Practical Medicinal Chemistry" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjK-Ec7VwvG-QGlwR0cXQhMmB-c3zVi6zE8ULwfVjsBhDdTVKlaoCLjuft-AC_cSFPrAoMfoxPhDwoRP2IhP5dna-kFKQR_6BNgecg0XYIpuYXB5RCZy2MbWbEKrbzOubhM8Sz5b3FWgW8/s1600/download_opt.jpg" title="Advanced Practical Medicinal Chemistry" /></a></div><div class="separator" style="clear: both; text-align: center;"><a href="http://p.pw/bad307" rel="nofollow" target="_blank">ttp://p.pw/bad307</a></div>

Advanced Practical Medicinal Chemistry

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ORGANIC MEDICINAL AND PHARMACEUTICA CHEMISTRY

<h2 style="text-align: center;"><span style="color: red; font-size: x-large;">Chemistry and creativity</span><span style="font-size: x-large;"> </span><span style="color: purple; font-size: x-large;">Wilson and Gisvold’s </span><span style="color: purple; font-size: x-large;">Textbook of </span><span style="color: blue; font-size: x-large;">Organic medicinal and pharmaceutical chemistry</span></h2><br /><div class="separator" style="clear: both; text-align: center;"></div><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgj4GHNu32c116QrksTZwB1zGsQVSNFakMHwVwpHKGn22bhbWDZBtox6Tjkm-uBl2iLKX63xt5bBoN3shJ0q071vi-BN0uQQ6OBEfk3A-DA8tApxWR8dNOwsiQCs6tBoB4ST5iInvveBHk/s1600/ORGANIC+MEDICINAL++AND+PHARMACEUTICAL+CHEMISTRY_opt_opt_opt.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgj4GHNu32c116QrksTZwB1zGsQVSNFakMHwVwpHKGn22bhbWDZBtox6Tjkm-uBl2iLKX63xt5bBoN3shJ0q071vi-BN0uQQ6OBEfk3A-DA8tApxWR8dNOwsiQCs6tBoB4ST5iInvveBHk/s1600/ORGANIC+MEDICINAL++AND+PHARMACEUTICAL+CHEMISTRY_opt_opt_opt.jpg" width="266" /></a></div><a name="more"></a><h3><strong style="color: purple; font-size: x-large;">Wilson and Gisvold’s Textbook of Organic medicinal and pharmaceutical chemistry</strong></h3><div class="separator" style="clear: both; text-align: center;"></div><div><div class="separator" style="clear: both; text-align: center;"></div>Edited by<a href="https://www.blogger.com/null" name="more"></a></div>John M. Beale, Jr., PhD<br />Associate Professor of <b>Medicinal Chemistry</b><br />Division of Basic and Pharmaceutical Sciences<br />St. Louis College of Pharmacy<br />Saint Louis, Missouri<br /><br />For 6 decades, <b>Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry</b> has been a standard in the literature of <b>medicinal chemistry</b>. Generations of students and faculty have depended on this textbook not only for undergraduate courses in <b>medicinal chemistry</b> but also as a supplement for graduate studies. Moreover, students in other health sciences have found certain chapters useful. The current editors and authors worked on the 12th edition with the objective of continuing the tradition of a modern textbook for undergraduate students and also for graduate students who need a general review of <b>medicinal chemistry</b>. Because the chapters include a blend of chemical and pharmacological principles necessary for understanding structure–activity relationships and molecular mechanisms of drug action, the book should be useful in supporting courses in <b>medicinal chemistry</b> and in complementing pharmacology courses.<br />The 12th edition follows in the footsteps of the 11th edition by reflecting the dynamic changes occurring in <b>medicinal chemistry</b>. With increased knowledge of the disease process and the identification of the key steps in the biochemical process, the chapters have been updated, expanded,<br />and reorganized. At the same time, to streamline the presentation of the content, some topics were<br />combined into existing chapters. For example, Chapter 2, “Drug Design Strategies,” incorporates<br />material from 11th edition Chapters 2, 3, and 28, and Chapter 3, “Metabolic Changes of Drugs and<br />Related Organic Compounds,” includes the content from 11th edition Chapter 5, “Prodrugs and<br />Drug Latentiation.” In addition, with the newer drugs that have entered the pharmaceutical armamentarium since publication of the 11th edition, coverage of the following topics has been expanded in the 12th edition: Central Dopaminergic Signaling Agents (Chapter 13), Anticonvulsants<br />(Chapter 14), Hormone-Related Disorders: Nonsteroidal Therapies (Chapter 20), Agents Treating<br />Bone Disorders (Chapter 21), and Anesthetics (Chapter 22).<br />New features of the 12th edition include a chapter overview at the beginning of each chapter to introduce material to be covered in the chapter and review questions at the end of each chapter to reinforce concepts learned in the chapter (answers to these questions are available to students on the book’s companion Web site; see next section).<br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjK-Ec7VwvG-QGlwR0cXQhMmB-c3zVi6zE8ULwfVjsBhDdTVKlaoCLjuft-AC_cSFPrAoMfoxPhDwoRP2IhP5dna-kFKQR_6BNgecg0XYIpuYXB5RCZy2MbWbEKrbzOubhM8Sz5b3FWgW8/s1600/download_opt.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Wilson and Gisvold’s Textbook of Organic medicinal and pharmaceutical chemistry" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjK-Ec7VwvG-QGlwR0cXQhMmB-c3zVi6zE8ULwfVjsBhDdTVKlaoCLjuft-AC_cSFPrAoMfoxPhDwoRP2IhP5dna-kFKQR_6BNgecg0XYIpuYXB5RCZy2MbWbEKrbzOubhM8Sz5b3FWgW8/s1600/download_opt.jpg" title="Wilson and Gisvold’s Textbook of Organic medicinal and pharmaceutical chemistry" /></a></div><div class="separator" style="clear: both; text-align: center;"><a href="http://www.mediafire.com/download/qrap8bwthmwy2ma/Org.midicinal_and_pharmaceutical_Chemistry.pdf" rel="nofollow" target="_blank">http://www.mediafire.com/download/qrap8bwthmwy2ma/Org.midicinal_and_pharmaceutical_Chemistry.pdf</a></div><div class="separator" style="clear: both; text-align: center;"></div>

ORGANIC MEDICINAL AND PHARMACEUTICA CHEMISTRY

Chemistry and creativity   Wilson and Gisvold’s  Textbook of  Organic medicinal and pharmaceutical chemistry Wilson and Gisvold’s Textbook o...

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Chemistry For Pharmacy Students - General, Organic Natural Product Chemistry

<h2><span style="font-size: x-large;"><span style="color: red;">Chemistry and creativity</span> <span style="color: blue;">Chemistry For Pharmacy Students</span><br /><span style="color: purple;">General, Organic & Natural Product Chemistry</span></span></h2><span style="color: blue;">Sarker, Satyajit D</span><br /><span style="color: blue;">Nahar, Lutfun Ph. D</span><br /><span style="color: blue;">Hoboken, N.J : Wiley </span><br /><span style="color: blue;">Chichester : John Wiley</span><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiG_Asy7VXotjKAP1TZJhT9VTM70r5Wy8XVrT2d5UYQXgo11XElendo3g6DPcie8wbNVgZDacZevff4d1D_P-GOCmoYyicQOLz1KDerRDPwN106Yzr9GjsdC5bzqQ6UNWCICaU46LE-SXI/s1600/Chemistry+For+Pharmacy+Students+-+General,+Organic+&+Natural+Product+Chemistry.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Chemistry For Pharmacy Students - General, Organic & Natural Product Chemistry" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiG_Asy7VXotjKAP1TZJhT9VTM70r5Wy8XVrT2d5UYQXgo11XElendo3g6DPcie8wbNVgZDacZevff4d1D_P-GOCmoYyicQOLz1KDerRDPwN106Yzr9GjsdC5bzqQ6UNWCICaU46LE-SXI/s1600/Chemistry+For+Pharmacy+Students+-+General,+Organic+&+Natural+Product+Chemistry.jpg" title="Chemistry For Pharmacy Students - General, Organic & Natural Product Chemistry" /></a></div><a name="more"></a><br /><a href="https://www.blogger.com/null" name="more"></a><br />Chemistry for Pharmacy Students is a student-friendly introduction to the key areas of chemistry required by all pharmacy and pharmaceutical science students. The book provides a comprehensive overview of the various areas of general, organic and natural product chemistry (in relation to drug molecules)<br /><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both; text-align: left;">Clearly structured to enhance student understanding, the book is divided into six clear sections. The book opens with an overview of general aspects of chemistry and their importance to modern life, with particular emphasis on medicinal applications. The text then moves on to a discussion of the concepts of atomic structure and bonding and the fundamentals of stereochemistry and the significance of each to pharmacy - in relation to drug action and toxicity. Various aspect s of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance are then covered, with final chapters looking at organic reactions and their applications to drug discovery and development and natural product chemistry.</div><div class="separator" style="clear: both; text-align: left;"><br /></div><div class="separator" style="clear: both;"><span style="color: purple; font-size: large;">Table of Contents</span></div><div class="separator" style="clear: both;"><br /></div><div class="separator" style="clear: both;">1 Introduction </div><div class="separator" style="clear: both;">1.1 Role of chemistry in modern life</div><div class="separator" style="clear: both;">1.2 Physical properties of drug molecules</div><div class="separator" style="clear: both;">2 Atomic structure and bonding </div><div class="separator" style="clear: both;">2.1 Atoms, elements and compounds </div><div class="separator" style="clear: both;">2.2 Atomic structure: orbitals and electronic configurations</div><div class="separator" style="clear: both;">2.3 Chemical bonding theories: formation of chemical bonds</div><div class="separator" style="clear: both;">2.4 Electronegativity and chemical bonding</div><div class="separator" style="clear: both;">2.5 Bond polarity and intermolecular forces </div><div class="separator" style="clear: both;">2.6 Significance of chemical bonding in drug–receptor interactions </div><div class="separator" style="clear: both;">3 Stereochemistry </div><div class="separator" style="clear: both;">3.1 Stereochemistry: definition</div><div class="separator" style="clear: both;">3.2 Isomerism</div><div class="separator" style="clear: both;">3.3 Significance of stereoisomerism in determining drug action and toxicity</div><div class="separator" style="clear: both;">3.4 Synthesis of chiral molecules</div><div class="separator" style="clear: both;">3.5 Separation of stereoisomers: resolution of racemic mixtures</div><div class="separator" style="clear: both;">3.6 Compounds with stereocentres other than carbon </div><div class="separator" style="clear: both;">3.7 Chiral compounds that do not have a tetrahedral atom with four different groups</div><div class="separator" style="clear: both;">4 Organic functional groups </div><div class="separator" style="clear: both;">4.1 Organic functional groups: definition and structural features</div><div class="separator" style="clear: both;">4.2 Hydrocarbons </div><div class="separator" style="clear: both;">4.3 Alkanes, cycloalkanes and their derivatives</div><div class="separator" style="clear: both;">4.4 Alkenes and their derivatives </div><div class="separator" style="clear: both;">4.5 Alkynes and their derivatives </div><div class="separator" style="clear: both;">4.6 Aromatic compounds and their derivatives</div><div class="separator" style="clear: both;">4.7 Heterocyclic compounds and their derivatives </div><div class="separator" style="clear: both;">4.8 Nucleic acids </div><div class="separator" style="clear: both;">4.9 Amino acids and peptides</div><div class="separator" style="clear: both;">4.10 Importance of functional groups in determining drug actions and toxicity </div><div class="separator" style="clear: both;">4.11 Importance of functional groups in determining stability of drugs </div><div class="separator" style="clear: both;">5 Organic reactions </div><div class="separator" style="clear: both;">5.1 Types of organic reaction</div><div class="separator" style="clear: both;">5.2 Radical reactions: free radical chain reactions </div><div class="separator" style="clear: both;">5.3 Addition reactions</div><div class="separator" style="clear: both;">5.4 Elimination reactions: 1,2-elimination or b-elimination </div><div class="separator" style="clear: both;">5.5 Substitution reactions </div><div class="separator" style="clear: both;">5.6 Hydrolysis </div><div class="separator" style="clear: both;">5.7 Oxidation–reduction reactions</div><div class="separator" style="clear: both;">5.8 Pericyclic reactions</div><div class="separator" style="clear: both;">6 Natural product chemistry </div><div class="separator" style="clear: both;">6.1 Introduction to natural product drug discovery process</div><div class="separator" style="clear: both;">6.2 Alkaloids </div><div class="separator" style="clear: both;">6.3 Carbohydrates</div><div class="separator" style="clear: both;">6.4 Glycosides</div><div class="separator" style="clear: both;">6.5 Terpenoids</div><div class="separator" style="clear: both;">6.6 Steroids</div><div class="separator" style="clear: both;">6.7 Phenolics</div><div class="separator" style="clear: both; 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Chemistry For Pharmacy Students - General, Organic Natural Product Chemistry

Chemistry and creativity   Chemistry For Pharmacy Students General, Organic & Natural Product Chemistry Sarker, Satyajit D Nahar, Lutfun...

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Encyclopedia of Analytical Chemistry Applications, Theory, and Instrumentation

<h2><span style="font-size: large;"><span style="color: blue;">Encyclopedia of Analytical Chemistry</span>: <span style="color: purple;">Applications, Theory, and Instrumentation, 15 Volume Set</span><span style="color: purple;">Robert A. Meyers (Editor-in-Chief) Free books,ebooks</span></span></h2><div style="text-align: center;"><img alt="Encyclopedia of Analytical Chemistry Applications, Theory, and Instrumentation" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhDKgDkS86qsT1nycps64DLsluybFUp5Wcl47jIdMz_CK2bdjyNNPvju8be9y4XliVFmU61_NxAu5f4t5q14C-ugKeJZDnLJkv9mjhpIaf1dH7MglmhGTY81s2FX6_GxeE3Pxt_FFZvZJM/s1600/Encyclopedia+of+Analytical+Chemistry+Free+chemistry+books_opt.jpg" title="Encyclopedia of Analytical Chemistry Applications, Theory, and Instrumentation" /><a name="more"></a></div><h3 style="clear: both; text-align: center;"><span style="font-size: large; text-align: left;">Encyclopedia of Analytical Chemistry </span></h3>The new 3-Volume Supplementary Set for <strong>Encyclopedia of Analytical Chemistry</strong> contains 95 new articles (published online in <b>Encyclopedia of Analytical Chemistry</b> (EAC) from 2008 – 2010), covering subjects which have achieved particular prominence and distinction since the print publication of EAC in 2000. The new 3 Volume Set includes advances in applications and theory ranging from mass spectrometry, atomic, infrared, Raman and X-ray spectroscopy, to nuclear magnetic resonance and imaging, nuclear methods, electrochemistry, and hyphenated techniques.<br />Provides essential information required to analyze elements and compounds as well as structures in a wide variety of matrices for a range of applications, interpret the results and also gain a thorough knowledge of the theory and instrumentation utilized.<br />Coverage of key advances includes:<br />Proteomics and genomics<br />Coverage of quantitative proteomics, electrochemical detection, dynamic light scattering, amyloids and protein aggregation measurements to low-cost, high-throughput gene sequencing<br />Imaging technologies<br /><br />Coverage of major new medical and biological techniques including: ultrashort laser pulse medical imaging,<br /><br /><span style="font-size: x-large;">Table of Contents</span><br />Supplementary Volume 1<br />Biomedical Spectroscopy.<br />Biomolecules Analysis.<br />Clinical Chemistry.<br />Environment: Water and Waste.<br />Field-portable Instrumentation.<br />Forensic Science.<br />Liquid Chromatography.<br />Nucleic Acids Structure and Mapping.<br />Peptides and Proteins.<br />Pharmaceuticals and Drugs.<br />Polymers and Rubbers.<br />Process Instrumental Methods.<br />Surfaces.<br />Supplementary Volume 2.<br />Atomic Spectroscopy.<br />Electroanalytical Methods.<br />Electronic Absorption and Luminescence.<br />Infrared Spectroscopy.<br />Mass Spectrometry.<br />Supplementary Volume 3.<br />Nuclear Magnetic Resonance and Electron Spin Resonance Spectroscopy.<br />Nuclear Methods.<br />Raman Spectroscopy.<br />X-Ray Spectrometry.<br />General Articles.<br />Appendices.<br />Lists of Index.<br /><h4>Download free Encyclopedia of Analytical Chemistry Applications, Theory, and Instrumentation</h4><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjK-Ec7VwvG-QGlwR0cXQhMmB-c3zVi6zE8ULwfVjsBhDdTVKlaoCLjuft-AC_cSFPrAoMfoxPhDwoRP2IhP5dna-kFKQR_6BNgecg0XYIpuYXB5RCZy2MbWbEKrbzOubhM8Sz5b3FWgW8/s1600/download_opt.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Encyclopedia of Analytical Chemistry Applications, Theory, and Instrumentation" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjK-Ec7VwvG-QGlwR0cXQhMmB-c3zVi6zE8ULwfVjsBhDdTVKlaoCLjuft-AC_cSFPrAoMfoxPhDwoRP2IhP5dna-kFKQR_6BNgecg0XYIpuYXB5RCZy2MbWbEKrbzOubhM8Sz5b3FWgW8/s1600/download_opt.jpg" title="Encyclopedia of Analytical Chemistry Applications, Theory, and Instrumentation" /></a></div><div class="separator" style="clear: both; text-align: center;"><a href="http://p.pw/badCbQ" rel="nofollow" target="_blank">http://p.pw/badCbQ</a></div><br /><!-- Blogger automated replacement: "https://images-blogger-opensocial.googleusercontent.com/gadgets/proxy?url=http%3A%2F%2F4.bp.blogspot.com%2F-wg9w6W6wTnI%2FVHWcJOnjQBI%2FAAAAAAAABpk%2FltKxocPKUkI%2Fs1600%2FEncyclopedia%252Bof%252BAnalytical%252BChemistry%252BFree%252Bchemistry%252Bbooks_opt.jpg&container=blogger&gadget=a&rewriteMime=image%2F*" with "https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhDKgDkS86qsT1nycps64DLsluybFUp5Wcl47jIdMz_CK2bdjyNNPvju8be9y4XliVFmU61_NxAu5f4t5q14C-ugKeJZDnLJkv9mjhpIaf1dH7MglmhGTY81s2FX6_GxeE3Pxt_FFZvZJM/s1600/Encyclopedia+of+Analytical+Chemistry+Free+chemistry+books_opt.jpg" -->

Encyclopedia of Analytical Chemistry Applications, Theory, and Instrumentation

Encyclopedia of Analytical Chemistry :  Applications, Theory, and Instrumentation, 15 Volume Set Robert A. Meyers (Editor-in-Chief) Free boo...

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