Chemistry and creativity Chemistry For Pharmacy Students
General, Organic & Natural Product Chemistry
Sarker, Satyajit DNahar, Lutfun Ph. D
Hoboken, N.J : Wiley
Chichester : John Wiley
Chemistry for Pharmacy Students is a student-friendly introduction to the key areas of chemistry required by all pharmacy and pharmaceutical science students. The book provides a comprehensive overview of the various areas of general, organic and natural product chemistry (in relation to drug molecules)
Clearly structured to enhance student understanding, the book is divided into six clear sections. The book opens with an overview of general aspects of chemistry and their importance to modern life, with particular emphasis on medicinal applications. The text then moves on to a discussion of the concepts of atomic structure and bonding and the fundamentals of stereochemistry and the significance of each to pharmacy - in relation to drug action and toxicity. Various aspect s of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance are then covered, with final chapters looking at organic reactions and their applications to drug discovery and development and natural product chemistry.
Table of Contents
1 Introduction
1.1 Role of chemistry in modern life
1.2 Physical properties of drug molecules
2 Atomic structure and bonding
2.1 Atoms, elements and compounds
2.2 Atomic structure: orbitals and electronic configurations
2.3 Chemical bonding theories: formation of chemical bonds
2.4 Electronegativity and chemical bonding
2.5 Bond polarity and intermolecular forces
2.6 Significance of chemical bonding in drug–receptor interactions
3 Stereochemistry
3.1 Stereochemistry: definition
3.2 Isomerism
3.3 Significance of stereoisomerism in determining drug action and toxicity
3.4 Synthesis of chiral molecules
3.5 Separation of stereoisomers: resolution of racemic mixtures
3.6 Compounds with stereocentres other than carbon
3.7 Chiral compounds that do not have a tetrahedral atom with four different groups
4 Organic functional groups
4.1 Organic functional groups: definition and structural features
4.2 Hydrocarbons
4.3 Alkanes, cycloalkanes and their derivatives
4.4 Alkenes and their derivatives
4.5 Alkynes and their derivatives
4.6 Aromatic compounds and their derivatives
4.7 Heterocyclic compounds and their derivatives
4.8 Nucleic acids
4.9 Amino acids and peptides
4.10 Importance of functional groups in determining drug actions and toxicity
4.11 Importance of functional groups in determining stability of drugs
5 Organic reactions
5.1 Types of organic reaction
5.2 Radical reactions: free radical chain reactions
5.3 Addition reactions
5.4 Elimination reactions: 1,2-elimination or b-elimination
5.5 Substitution reactions
5.6 Hydrolysis
5.7 Oxidation–reduction reactions
5.8 Pericyclic reactions
6 Natural product chemistry
6.1 Introduction to natural product drug discovery process
6.2 Alkaloids
6.3 Carbohydrates
6.4 Glycosides
6.5 Terpenoids
6.6 Steroids
6.7 Phenolics
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